- DPH1
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DPH1 homolog (S. cerevisiae) Identifiers Symbols DPH1; DPH2L; DPH2L1; FLJ33211; OVCA1 External IDs OMIM: 603527 HomoloGene: 1059 GeneCards: DPH1 Gene Gene Ontology Cellular component • nucleus
• cytoplasmBiological process • translation
• cell proliferation
• peptidyl-diphthamide biosynthetic process from peptidyl-histidineSources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 1801 116905 Ensembl ENSG00000108963 ENSMUSG00000078789 UniProt Q9BZG8 n/a RefSeq (mRNA) NM_001383 NM_144491.2 RefSeq (protein) NP_001374 NP_652762.2 Location (UCSC) Chr 17:
1.93 – 1.95 MbChr 11:
74.99 – 75 MbPubMed search [1] [2] Diphthamide biosynthesis protein 1 is a protein that in humans is encoded by the DPH1 gene.[1][2][3] It encodes a protein that modifies histidine-699 on eukaryotic translation elongation factor 2 to diphthamide. This modification appears to be important in the translation (genetics) of Cyclin D in ovarian cells. OVCA1 is mutated in 90% of ovarian cancers end stage, usually by loss of heterozygosity.
References
- ^ Phillips NJ, Zeigler MR, Deaven LL (May 1996). "A cDNA from the ovarian cancer critical region of deletion on chromosome 17p13.3". Cancer Lett 102 (1-2): 85–90. doi:10.1016/0304-3835(96)04169-9. PMID 8603384.
- ^ Liu S, Milne GT, Kuremsky JG, Fink GR, Leppla SH (Oct 2004). "Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2". Mol Cell Biol 24 (21): 9487–97. doi:10.1128/MCB.24.21.9487-9497.2004. PMC 522255. PMID 15485916. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=522255.
- ^ "Entrez Gene: DPH1 DPH1 homolog (S. cerevisiae)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1801.
Further reading
- Schultz DC, Vanderveer L, Berman DB, et al. (1996). "Identification of two candidate tumor suppressor genes on chromosome 17p13.3.". Cancer Res. 56 (9): 1997–2002. PMID 8616839.
- Bruening W, Prowse AH, Schultz DC, et al. (1999). "Expression of OVCA1, a candidate tumor suppressor, is reduced in tumors and inhibits growth of ovarian cancer cells.". Cancer Res. 59 (19): 4973–83. PMID 10519411.
- Salicioni AM, Xi M, Vanderveer LA, et al. (2001). "Identification and structural analysis of human RBM8A and RBM8B: two highly conserved RNA-binding motif proteins that interact with OVCA1, a candidate tumor suppressor.". Genomics 69 (1): 54–62. doi:10.1006/geno.2000.6315. PMID 11013075.
- Chen CM, Behringer RR (2001). "Cloning, structure, and expression of the mouse Ovca1 gene.". Biochem. Biophys. Res. Commun. 286 (5): 1019–26. doi:10.1006/bbrc.2001.5488. PMID 11527402.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
- Cardoso C, Leventer RJ, Ward HL, et al. (2003). "Refinement of a 400-kb critical region allows genotypic differentiation between isolated lissencephaly, Miller-Dieker syndrome, and other phenotypes secondary to deletions of 17p13.3.". Am. J. Hum. Genet. 72 (4): 918–30. doi:10.1086/374320. PMC 1180354. PMID 12621583. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1180354.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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