UPF1

UPF1 regulator of nonsense transcripts homolog (yeast), also known as UPF1, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located only in the cytoplasm. When translation ends, it interacts with the protein that is a functional homolog of yeast Upf2p to trigger mRNA decapping. Use of multiple polyadenylation sites has been noted for this gene.cite web | title = Entrez Gene: UPF1 UPF1 regulator of nonsense transcripts homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5976| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Azzalin CM, Lingner J |title=The double life of UPF1 in RNA and DNA stability pathways. |journal=Cell Cycle |volume=5 |issue= 14 |pages= 1496–8 |year= 2006 |pmid= 16861888 |doi=
*cite journal | author=Horikoshi M, Sekimizu K, Natori S |title=Analysis of the stimulatory factor of RNA polymerase II in the initiation and elongation complex. |journal=J. Biol. Chem. |volume=259 |issue= 1 |pages= 608–11 |year= 1984 |pmid= 6200476 |doi=
*cite journal | author=Perlick HA, Medghalchi SM, Spencer FA, "et al." |title=Mammalian orthologues of a yeast regulator of nonsense transcript stability. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 20 |pages= 10928–32 |year= 1996 |pmid= 8855285 |doi=
*cite journal | author=Nagase T, Seki N, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=
*cite journal | author=Applequist SE, Selg M, Raman C, Jäck HM |title=Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 protein. |journal=Nucleic Acids Res. |volume=25 |issue= 4 |pages= 814–21 |year= 1997 |pmid= 9064659 |doi=
*cite journal | author=Czaplinski K, Ruiz-Echevarria MJ, Paushkin SV, "et al." |title=The surveillance complex interacts with the translation release factors to enhance termination and degrade aberrant mRNAs. |journal=Genes Dev. |volume=12 |issue= 11 |pages= 1665–77 |year= 1998 |pmid= 9620853 |doi=
*cite journal | author=Page MF, Carr B, Anders KR, "et al." |title=SMG-2 is a phosphorylated protein required for mRNA surveillance in Caenorhabditis elegans and related to Upf1p of yeast. |journal=Mol. Cell. Biol. |volume=19 |issue= 9 |pages= 5943–51 |year= 1999 |pmid= 10454541 |doi=
*cite journal | author=Bhattacharya A, Czaplinski K, Trifillis P, "et al." |title=Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay. |journal=RNA |volume=6 |issue= 9 |pages= 1226–35 |year= 2000 |pmid= 10999600 |doi=
*cite journal | author=Mendell JT, Medghalchi SM, Lake RG, "et al." |title=Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8944–57 |year= 2000 |pmid= 11073994 |doi=
*cite journal | author=Serin G, Gersappe A, Black JD, "et al." |title=Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). |journal=Mol. Cell. Biol. |volume=21 |issue= 1 |pages= 209–23 |year= 2001 |pmid= 11113196 |doi= 10.1128/MCB.21.1.209-223.2001
*cite journal | author=Lykke-Andersen J, Shu MD, Steitz JA |title=Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. |journal=Cell |volume=103 |issue= 7 |pages= 1121–31 |year= 2001 |pmid= 11163187 |doi=
*cite journal | author=Denning G, Jamieson L, Maquat LE, "et al." |title=Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22709–14 |year= 2001 |pmid= 11331269 |doi= 10.1074/jbc.C100144200
*cite journal | author=Yamashita A, Ohnishi T, Kashima I, "et al." |title=Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. |journal=Genes Dev. |volume=15 |issue= 17 |pages= 2215–28 |year= 2001 |pmid= 11544179 |doi= 10.1101/gad.913001
*cite journal | author=Lykke-Andersen J, Shu MD, Steitz JA |title=Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. |journal=Science |volume=293 |issue= 5536 |pages= 1836–9 |year= 2001 |pmid= 11546874 |doi= 10.1126/science.1062786
*cite journal | author=Carastro LM, Tan CK, Selg M, "et al." |title=Identification of delta helicase as the bovine homolog of HUPF1: demonstration of an interaction with the third subunit of DNA polymerase delta. |journal=Nucleic Acids Res. |volume=30 |issue= 10 |pages= 2232–43 |year= 2002 |pmid= 12000843 |doi=
*cite journal | author=Mendell JT, ap Rhys CM, Dietz HC |title=Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts. |journal=Science |volume=298 |issue= 5592 |pages= 419–22 |year= 2002 |pmid= 12228722 |doi= 10.1126/science.1074428
*cite journal | author=Lykke-Andersen J |title=Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. |journal=Mol. Cell. Biol. |volume=22 |issue= 23 |pages= 8114–21 |year= 2003 |pmid= 12417715 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chiu SY, Serin G, Ohara O, Maquat LE |title=Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. |journal=RNA |volume=9 |issue= 1 |pages= 77–87 |year= 2003 |pmid= 12554878 |doi=
*cite journal | author=Schell T, Köcher T, Wilm M, "et al." |title=Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. |journal=Biochem. J. |volume=373 |issue= Pt 3 |pages= 775–83 |year= 2003 |pmid= 12723973 |doi= 10.1042/BJ20021920

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