CASC3

Cancer susceptibility candidate 3, also known as CASC3, is a human gene.cite web | title = Entrez Gene: CASC3 cancer susceptibility candidate 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22794| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene is a core component of the exon junction complex (EJC), a protein complex that is deposited on spliced mRNAs at exon-exon junctions and functions in nonsense-mediated mRNA decay (NMD). The encoded protein binds RNA and interacts with two other EJC core components. It is predominantly located in the cytoplasm, but shuttles into the nucleus where it localizes to nuclear speckles.cite web | title = Entrez Gene: CASC3 cancer susceptibility candidate 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22794| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tomasetto C, Régnier C, Moog-Lutz C, "et al." |title=Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17. |journal=Genomics |volume=28 |issue= 3 |pages= 367–76 |year= 1996 |pmid= 7490069 |doi= 10.1006/geno.1995.1163
*cite journal | author=Varis A, Wolf M, Monni O, "et al." |title=Targets of gene amplification and overexpression at 17q in gastric cancer. |journal=Cancer Res. |volume=62 |issue= 9 |pages= 2625–9 |year= 2002 |pmid= 11980659 |doi=
*cite journal | author=Degot S, Régnier CH, Wendling C, "et al." |title=Metastatic Lymph Node 51, a novel nucleo-cytoplasmic protein overexpressed in breast cancer. |journal=Oncogene |volume=21 |issue= 28 |pages= 4422–34 |year= 2002 |pmid= 12080473 |doi= 10.1038/sj.onc.1205611
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Macchi P, Kroening S, Palacios IM, "et al." |title=Barentsz, a new component of the Staufen-containing ribonucleoprotein particles in mammalian cells, interacts with Staufen in an RNA-dependent manner. |journal=J. Neurosci. |volume=23 |issue= 13 |pages= 5778–88 |year= 2003 |pmid= 12843282 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Palacios IM, Gatfield D, St Johnston D, Izaurralde E |title=An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decay. |journal=Nature |volume=427 |issue= 6976 |pages= 753–7 |year= 2004 |pmid= 14973490 |doi= 10.1038/nature02351
*cite journal | author=Degot S, Le Hir H, Alpy F, "et al." |title=Association of the breast cancer protein MLN51 with the exon junction complex via its speckle localizer and RNA binding module. |journal=J. Biol. Chem. |volume=279 |issue= 32 |pages= 33702–15 |year= 2004 |pmid= 15166247 |doi= 10.1074/jbc.M402754200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kim YK, Furic L, Desgroseillers L, Maquat LE |title=Mammalian Staufen1 recruits Upf1 to specific mRNA 3'UTRs so as to elicit mRNA decay. |journal=Cell |volume=120 |issue= 2 |pages= 195–208 |year= 2005 |pmid= 15680326 |doi= 10.1016/j.cell.2004.11.050
*cite journal | author=Ballut L, Marchadier B, Baguet A, "et al." |title=The exon junction core complex is locked onto RNA by inhibition of eIF4AIII ATPase activity. |journal=Nat. Struct. Mol. Biol. |volume=12 |issue= 10 |pages= 861–9 |year= 2005 |pmid= 16170325 |doi= 10.1038/nsmb990
*cite journal | author=Tange TØ, Shibuya T, Jurica MS, Moore MJ |title=Biochemical analysis of the EJC reveals two new factors and a stable tetrameric protein core. |journal=RNA |volume=11 |issue= 12 |pages= 1869–83 |year= 2006 |pmid= 16314458 |doi= 10.1261/rna.2155905
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Shibuya T, Tange TØ, Stroupe ME, Moore MJ |title=Mutational analysis of human eIF4AIII identifies regions necessary for exon junction complex formation and nonsense-mediated mRNA decay. |journal=RNA |volume=12 |issue= 3 |pages= 360–74 |year= 2006 |pmid= 16495234 |doi= 10.1261/rna.2190706
*cite journal | author=Andersen CB, Ballut L, Johansen JS, "et al." |title=Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA. |journal=Science |volume=313 |issue= 5795 |pages= 1968–72 |year= 2006 |pmid= 16931718 |doi= 10.1126/science.1131981
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Baguet A, Degot S, Cougot N, "et al." |title=The exon-junction-complex-component metastatic lymph node 51 functions in stress-granule assembly. |journal=J. Cell. Sci. |volume=120 |issue= Pt 16 |pages= 2774–84 |year= 2007 |pmid= 17652158 |doi= 10.1242/jcs.009225

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