SMG1 (gene)

PI-3-kinase-related kinase SMG-1, also known as SMG1, is a human gene.cite web | title = Entrez Gene: SMG1 PI-3-kinase-related kinase SMG-1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23049| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein involved in nonsense-mediated mRNA decay (NMD) as part of the mRNA surveillance complex. The protein has kinase activity and is thought to function in NMD by phosphorylating the regulator of nonsense transcripts 1 protein. Alternative spliced transcript variants have been described, but their full-length natures have not been determined.cite web | title = Entrez Gene: SMG1 PI-3-kinase-related kinase SMG-1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23049| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Abraham RT |title=The ATM-related kinase, hSMG-1, bridges genome and RNA surveillance pathways. |journal=DNA Repair (Amst.) |volume=3 |issue= 8-9 |pages= 919–25 |year= 2005 |pmid= 15279777 |doi= 10.1016/j.dnarep.2004.04.003
*cite journal | author=Diaz-Meco MT, Municio MM, Sanchez P, "et al." |title=Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo. |journal=Mol. Cell. Biol. |volume=16 |issue= 1 |pages= 105–14 |year= 1996 |pmid= 8524286 |doi=
*cite journal | author=Ishikawa K, Nagase T, Nakajima D, "et al." |title=Prediction of the coding sequences of unidentified human genes. VIII. 78 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=4 |issue= 5 |pages= 307–13 |year= 1998 |pmid= 9455477 |doi=
*cite journal | author=Sanchez P, De Carcer G, Sandoval IV, "et al." |title=Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 3069–80 |year= 1998 |pmid= 9566925 |doi=
*cite journal | author=Carmeliet P, Lampugnani MG, Moons L, "et al." |title=Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. |journal=Cell |volume=98 |issue= 2 |pages= 147–57 |year= 1999 |pmid= 10428027 |doi=
*cite journal | author=Loftus BJ, Kim UJ, Sneddon VP, "et al." |title=Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q. |journal=Genomics |volume=60 |issue= 3 |pages= 295–308 |year= 1999 |pmid= 10493829 |doi= 10.1006/geno.1999.5927
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Denning G, Jamieson L, Maquat LE, "et al." |title=Cloning of a novel phosphatidylinositol kinase-related kinase: characterization of the human SMG-1 RNA surveillance protein. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 22709–14 |year= 2001 |pmid= 11331269 |doi= 10.1074/jbc.C100144200
*cite journal | author=Yamashita A, Ohnishi T, Kashima I, "et al." |title=Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. |journal=Genes Dev. |volume=15 |issue= 17 |pages= 2215–28 |year= 2001 |pmid= 11544179 |doi= 10.1101/gad.913001
*cite journal | author=Eichler EE, Johnson ME, Alkan C, "et al." |title=Divergent origins and concerted expansion of two segmental duplications on chromosome 16. |journal=J. Hered. |volume=92 |issue= 6 |pages= 462–8 |year= 2002 |pmid= 11948212 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chiu SY, Serin G, Ohara O, Maquat LE |title=Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. |journal=RNA |volume=9 |issue= 1 |pages= 77–87 |year= 2003 |pmid= 12554878 |doi=
*cite journal | author=Ohnishi T, Yamashita A, Kashima I, "et al." |title=Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1187–200 |year= 2004 |pmid= 14636577 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Brumbaugh KM, Otterness DM, Geisen C, "et al." |title=The mRNA surveillance protein hSMG-1 functions in genotoxic stress response pathways in mammalian cells. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 585–98 |year= 2004 |pmid= 15175154 |doi= 10.1016/j.molcel.2004.05.005
*cite journal | author=Kashima I, Yamashita A, Izumi N, "et al." |title=Binding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decay. |journal=Genes Dev. |volume=20 |issue= 3 |pages= 355–67 |year= 2006 |pmid= 16452507 |doi= 10.1101/gad.1389006
*cite journal | author=Azzalin CM, Lingner J |title=The human RNA surveillance factor UPF1 is required for S phase progression and genome stability. |journal=Curr. Biol. |volume=16 |issue= 4 |pages= 433–9 |year= 2006 |pmid= 16488880 |doi= 10.1016/j.cub.2006.01.018

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