UPF2

UPF2 regulator of nonsense transcripts homolog (yeast), also known as UPF2, is a human gene.cite web | title = Entrez Gene: UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26019| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein.cite web | title = Entrez Gene: UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26019| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wilson KF, Fortes P, Singh US, "et al." |title=The nuclear cap-binding complex is a novel target of growth factor receptor-coupled signal transduction. |journal=J. Biol. Chem. |volume=274 |issue= 7 |pages= 4166–73 |year= 1999 |pmid= 9933612 |doi=
*cite journal | author=Nagase T, Kikuno R, Ishikawa KI, "et al." |title=Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=7 |issue= 1 |pages= 65–73 |year= 2000 |pmid= 10718198 |doi=
*cite journal | author=Mendell JT, Medghalchi SM, Lake RG, "et al." |title=Novel Upf2p orthologues suggest a functional link between translation initiation and nonsense surveillance complexes. |journal=Mol. Cell. Biol. |volume=20 |issue= 23 |pages= 8944–57 |year= 2000 |pmid= 11073994 |doi=
*cite journal | author=Serin G, Gersappe A, Black JD, "et al." |title=Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4). |journal=Mol. Cell. Biol. |volume=21 |issue= 1 |pages= 209–23 |year= 2001 |pmid= 11113196 |doi= 10.1128/MCB.21.1.209-223.2001
*cite journal | author=Lykke-Andersen J, Shu MD, Steitz JA |title=Human Upf proteins target an mRNA for nonsense-mediated decay when bound downstream of a termination codon. |journal=Cell |volume=103 |issue= 7 |pages= 1121–31 |year= 2001 |pmid= 11163187 |doi=
*cite journal | author=Yamashita A, Ohnishi T, Kashima I, "et al." |title=Human SMG-1, a novel phosphatidylinositol 3-kinase-related protein kinase, associates with components of the mRNA surveillance complex and is involved in the regulation of nonsense-mediated mRNA decay. |journal=Genes Dev. |volume=15 |issue= 17 |pages= 2215–28 |year= 2001 |pmid= 11544179 |doi= 10.1101/gad.913001
*cite journal | author=Lykke-Andersen J, Shu MD, Steitz JA |title=Communication of the position of exon-exon junctions to the mRNA surveillance machinery by the protein RNPS1. |journal=Science |volume=293 |issue= 5536 |pages= 1836–9 |year= 2001 |pmid= 11546874 |doi= 10.1126/science.1062786
*cite journal | author=Lejeune F, Ishigaki Y, Li X, Maquat LE |title=The exon junction complex is detected on CBP80-bound but not eIF4E-bound mRNA in mammalian cells: dynamics of mRNP remodeling. |journal=EMBO J. |volume=21 |issue= 13 |pages= 3536–45 |year= 2002 |pmid= 12093754 |doi= 10.1093/emboj/cdf345
*cite journal | author=Lykke-Andersen J |title=Identification of a human decapping complex associated with hUpf proteins in nonsense-mediated decay. |journal=Mol. Cell. Biol. |volume=22 |issue= 23 |pages= 8114–21 |year= 2003 |pmid= 12417715 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Chiu SY, Serin G, Ohara O, Maquat LE |title=Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1. |journal=RNA |volume=9 |issue= 1 |pages= 77–87 |year= 2003 |pmid= 12554878 |doi=
*cite journal | author=Gehring NH, Neu-Yilik G, Schell T, "et al." |title=Y14 and hUpf3b form an NMD-activating complex. |journal=Mol. Cell |volume=11 |issue= 4 |pages= 939–49 |year= 2003 |pmid= 12718880 |doi=
*cite journal | author=Schell T, Köcher T, Wilm M, "et al." |title=Complexes between the nonsense-mediated mRNA decay pathway factor human upf1 (up-frameshift protein 1) and essential nonsense-mediated mRNA decay factors in HeLa cells. |journal=Biochem. J. |volume=373 |issue= Pt 3 |pages= 775–83 |year= 2003 |pmid= 12723973 |doi= 10.1042/BJ20021920
*cite journal | author=Lejeune F, Li X, Maquat LE |title=Nonsense-mediated mRNA decay in mammalian cells involves decapping, deadenylating, and exonucleolytic activities. |journal=Mol. Cell |volume=12 |issue= 3 |pages= 675–87 |year= 2003 |pmid= 14527413 |doi=
*cite journal | author=Mungall AJ, Palmer SA, Sims SK, "et al." |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055
*cite journal | author=Ohnishi T, Yamashita A, Kashima I, "et al." |title=Phosphorylation of hUPF1 induces formation of mRNA surveillance complexes containing hSMG-5 and hSMG-7. |journal=Mol. Cell |volume=12 |issue= 5 |pages= 1187–200 |year= 2004 |pmid= 14636577 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Kadlec J, Izaurralde E, Cusack S |title=The structural basis for the interaction between nonsense-mediated mRNA decay factors UPF2 and UPF3. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 4 |pages= 330–7 |year= 2004 |pmid= 15004547 |doi= 10.1038/nsmb741
*cite journal | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004
*cite journal | author=Lejeune F, Ranganathan AC, Maquat LE |title=eIF4G is required for the pioneer round of translation in mammalian cells. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 10 |pages= 992–1000 |year= 2004 |pmid= 15361857 |doi= 10.1038/nsmb824

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