CD2AP

CD2-associated protein, also known as CD2AP, is a human gene.cite web | title = Entrez Gene: CD2AP CD2-associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23607| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a scaffolding molecule that regulates the actin cytoskeleton. The protein directly interacts with filamentous actin and a variety of cell membrane proteins through multiple actin binding sites, SH3 domains, and a proline-rich region containing binding sites for SH3 domains. The cytoplasmic protein localizes to membrane ruffles, lipid rafts, and the leading edges of cells. It is implicated in dynamic actin remodeling and membrane trafficking that occurs during receptor endocytosis and cytokinesis. Haploinsufficiency of this gene is implicated in susceptibility to glomerular disease.cite web | title = Entrez Gene: CD2AP CD2-associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23607| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Dustin ML, Olszowy MW, Holdorf AD, "et al." |title=A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T-cell contacts. |journal=Cell |volume=94 |issue= 5 |pages= 667–77 |year= 1998 |pmid= 9741631 |doi=
*cite journal | author=Kirsch KH, Georgescu MM, Ishimaru S, Hanafusa H |title=CMS: an adapter molecule involved in cytoskeletal rearrangements. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 11 |pages= 6211–6 |year= 1999 |pmid= 10339567 |doi=
*cite journal | author=Lehtonen S, Ora A, Olkkonen VM, "et al." |title=In vivo interaction of the adapter protein CD2-associated protein with the type 2 polycystic kidney disease protein, polycystin-2. |journal=J. Biol. Chem. |volume=275 |issue= 42 |pages= 32888–93 |year= 2000 |pmid= 10913159 |doi= 10.1074/jbc.M006624200
*cite journal | author=Li C, Ruotsalainen V, Tryggvason K, "et al." |title=CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere. |journal=Am. J. Physiol. Renal Physiol. |volume=279 |issue= 4 |pages= F785–92 |year= 2000 |pmid= 10997929 |doi=
*cite journal | author=Kirsch KH, Georgescu MM, Shishido T, "et al." |title=The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src homology 3 domain interaction. |journal=J. Biol. Chem. |volume=276 |issue= 7 |pages= 4957–63 |year= 2001 |pmid= 11067845 |doi= 10.1074/jbc.M005784200
*cite journal | author=Schwarz K, Simons M, Reiser J, "et al." |title=Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin. |journal=J. Clin. Invest. |volume=108 |issue= 11 |pages= 1621–9 |year= 2002 |pmid= 11733557 |doi=
*cite journal | author=Scott MP, Zappacosta F, Kim EY, "et al." |title=Identification of novel SH3 domain ligands for the Src family kinase Hck. Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 28238–46 |year= 2002 |pmid= 12029088 |doi= 10.1074/jbc.M202783200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Badour K, Zhang J, Shi F, "et al." |title=The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. |journal=Immunity |volume=18 |issue= 1 |pages= 141–54 |year= 2003 |pmid= 12530983 |doi=
*cite journal | author=Cormont M, Metón I, Mari M, "et al." |title=CD2AP/CMS regulates endosome morphology and traffic to the degradative pathway through its interaction with Rab4 and c-Cbl. |journal=Traffic |volume=4 |issue= 2 |pages= 97–112 |year= 2003 |pmid= 12559036 |doi=
*cite journal | author=Lynch DK, Winata SC, Lyons RJ, "et al." |title=A Cortactin-CD2-associated protein (CD2AP) complex provides a novel link between epidermal growth factor receptor endocytosis and the actin cytoskeleton. |journal=J. Biol. Chem. |volume=278 |issue= 24 |pages= 21805–13 |year= 2003 |pmid= 12672817 |doi= 10.1074/jbc.M211407200
*cite journal | author=Hutchings NJ, Clarkson N, Chalkley R, "et al." |title=Linking the T cell surface protein CD2 to the actin-capping protein CAPZ via CMS and CIN85. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 22396–403 |year= 2003 |pmid= 12690097 |doi= 10.1074/jbc.M302540200
*cite journal | author=Kim JM, Wu H, Green G, "et al." |title=CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility. |journal=Science |volume=300 |issue= 5623 |pages= 1298–300 |year= 2003 |pmid= 12764198 |doi= 10.1126/science.1081068
*cite journal | author=Schulze WX, Mann M |title=A novel proteomic screen for peptide-protein interactions. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10756–64 |year= 2004 |pmid= 14679214 |doi= 10.1074/jbc.M309909200
*cite journal | author=Haglund K, Ivankovic-Dikic I, Shimokawa N, "et al." |title=Recruitment of Pyk2 and Cbl to lipid rafts mediates signals important for actin reorganization in growing neurites. |journal=J. Cell. Sci. |volume=117 |issue= Pt 12 |pages= 2557–68 |year= 2004 |pmid= 15128873 |doi= 10.1242/jcs.01148
*cite journal | author=Lehtonen S, Lehtonen E, Kudlicka K, "et al." |title=Nephrin forms a complex with adherens junction proteins and CASK in podocytes and in Madin-Darby canine kidney cells expressing nephrin. |journal=Am. J. Pathol. |volume=165 |issue= 3 |pages= 923–36 |year= 2004 |pmid= 15331416 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046
*cite journal | author=Coward RJ, Foster RR, Patton D, "et al." |title=Nephrotic plasma alters slit diaphragm-dependent signaling and translocates nephrin, Podocin, and CD2 associated protein in cultured human podocytes. |journal=J. Am. Soc. Nephrol. |volume=16 |issue= 3 |pages= 629–37 |year= 2005 |pmid= 15659563 |doi= 10.1681/ASN.2004030172

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