POT1

POT1

POT1 protection of telomeres 1 homolog (S. pombe), also known as POT1, is a human gene.cite web | title = Entrez Gene: POT1 POT1 protection of telomeres 1 homolog (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25913| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the telombin family and encodes a nuclear protein involved in telomere maintenance. Specifically, this protein functions as a member of a multi-protein complex that binds to the TTAGGG repeats of telomeres, regulating telomere length and protecting chromosome ends from illegitimate recombination, catastrophic chromosome instability, and abnormal chromosome segregation. Increased transcriptional expression of this gene is associated with stomach carcinogenesis and its progression. Alternatively spliced transcript variants have been described.cite web | title = Entrez Gene: POT1 POT1 protection of telomeres 1 homolog (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25913| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=de Lange T |title=Shelterin: the protein complex that shapes and safeguards human telomeres. |journal=Genes Dev. |volume=19 |issue= 18 |pages= 2100–10 |year= 2005 |pmid= 16166375 |doi= 10.1101/gad.1346005
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Baumann P, Cech TR |title=Pot1, the putative telomere end-binding protein in fission yeast and humans. |journal=Science |volume=292 |issue= 5519 |pages= 1171–5 |year= 2001 |pmid= 11349150 |doi= 10.1126/science.1060036
*cite journal | author=Baumann P, Podell E, Cech TR |title=Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing. |journal=Mol. Cell. Biol. |volume=22 |issue= 22 |pages= 8079–87 |year= 2002 |pmid= 12391173 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Loayza D, De Lange T |title=POT1 as a terminal transducer of TRF1 telomere length control. |journal=Nature |volume=423 |issue= 6943 |pages= 1013–8 |year= 2003 |pmid= 12768206 |doi= 10.1038/nature01688
*cite journal | author=Colgin LM, Baran K, Baumann P, "et al." |title=Human POT1 facilitates telomere elongation by telomerase. |journal=Curr. Biol. |volume=13 |issue= 11 |pages= 942–6 |year= 2004 |pmid= 12781132 |doi=
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Loayza D, Parsons H, Donigian J, "et al." |title=DNA binding features of human POT1: a nonamer 5'-TAGGGTTAG-3' minimal binding site, sequence specificity, and internal binding to multimeric sites. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 13241–8 |year= 2004 |pmid= 14715659 |doi= 10.1074/jbc.M312309200
*cite journal | author=Kondo T, Oue N, Yoshida K, "et al." |title=Expression of POT1 is associated with tumor stage and telomere length in gastric carcinoma. |journal=Cancer Res. |volume=64 |issue= 2 |pages= 523–9 |year= 2004 |pmid= 14744765 |doi=
*cite journal | author=Armbruster BN, Linardic CM, Veldman T, "et al." |title=Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. |journal=Mol. Cell. Biol. |volume=24 |issue= 8 |pages= 3552–61 |year= 2004 |pmid= 15060173 |doi=
*cite journal | author=Liu D, Safari A, O'Connor MS, "et al." |title=PTOP interacts with POT1 and regulates its localization to telomeres. |journal=Nat. Cell Biol. |volume=6 |issue= 7 |pages= 673–80 |year= 2004 |pmid= 15181449 |doi= 10.1038/ncb1142
*cite journal | author=Ye JZ, Hockemeyer D, Krutchinsky AN, "et al." |title=POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. |journal=Genes Dev. |volume=18 |issue= 14 |pages= 1649–54 |year= 2004 |pmid= 15231715 |doi= 10.1101/gad.1215404
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Lei M, Podell ER, Cech TR |title=Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 12 |pages= 1223–9 |year= 2005 |pmid= 15558049 |doi= 10.1038/nsmb867
*cite journal | author=Veldman T, Etheridge KT, Counter CM |title=Loss of hPot1 function leads to telomere instability and a cut-like phenotype. |journal=Curr. Biol. |volume=14 |issue= 24 |pages= 2264–70 |year= 2005 |pmid= 15620654 |doi= 10.1016/j.cub.2004.12.031
*cite journal | author=Kelleher C, Kurth I, Lingner J |title=Human protection of telomeres 1 (POT1) is a negative regulator of telomerase activity in vitro. |journal=Mol. Cell. Biol. |volume=25 |issue= 2 |pages= 808–18 |year= 2005 |pmid= 15632080 |doi= 10.1128/MCB.25.2.808-818.2005
*cite journal | author=Yang Q, Zheng YL, Harris CC |title=POT1 and TRF2 cooperate to maintain telomeric integrity. |journal=Mol. Cell. Biol. |volume=25 |issue= 3 |pages= 1070–80 |year= 2005 |pmid= 15657433 |doi= 10.1128/MCB.25.3.1070-1080.2005
*cite journal | author=Lei M, Zaug AJ, Podell ER, Cech TR |title=Switching human telomerase on and off with hPOT1 protein in vitro. |journal=J. Biol. Chem. |volume=280 |issue= 21 |pages= 20449–56 |year= 2005 |pmid= 15792951 |doi= 10.1074/jbc.M502212200

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