SART3

Squamous cell carcinoma antigen recognized by T cells 3, also known as SART3, is a human gene.cite web | title = Entrez Gene: SART3 squamous cell carcinoma antigen recognized by T cells 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9733| accessdate = ] cite journal | author = Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N | title = Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Res. | volume = 2 | issue = 4 | pages = 167–74, 199–210 | year = 1995 | month = August | pmid = 8590280 | doi = 10.1093/dnares/2.4.167 | url = | issn = ] cite journal | author = Harada K, Yamada A, Mine T, Kawagoe N, Takasu H, Itoh K | title = Mouse homologue of the human SART3 gene encoding tumor-rejection antigen | journal = Jpn. J. Cancer Res. | volume = 91 | issue = 2 | pages = 239–47 | year = 2000 | month = February | pmid = 10761712 | url = | issn = ]

The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Nagase T, Seki N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Yang D, Nakao M, Shichijo S, "et al." |title=Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients. |journal=Cancer Res. |volume=59 |issue= 16 |pages= 4056–63 |year= 1999 |pmid= 10463607 |doi=
*cite journal | author=Harada K, Yamada A, Mine T, "et al." |title=Mouse homologue of the human SART3 gene encoding tumor-rejection antigen. |journal=Jpn. J. Cancer Res. |volume=91 |issue= 2 |pages= 239–47 |year= 2000 |pmid= 10761712 |doi=
*cite journal | author=Tanaka S, Tsuda N, Kawano K, "et al." |title=Expression of tumor-rejection antigens in gynecologic cancers. |journal=Jpn. J. Cancer Res. |volume=91 |issue= 11 |pages= 1177–84 |year= 2001 |pmid= 11092984 |doi=
*cite journal | author=Harada K, Yamada A, Yang D, "et al." |title=Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation. |journal=Int. J. Cancer |volume=93 |issue= 5 |pages= 623–8 |year= 2001 |pmid= 11477570 |doi=
*cite journal | author=Sasatomi T, Suefuji Y, Matsunaga K, "et al." |title=Expression of tumor rejection antigens in colorectal carcinomas. |journal=Cancer |volume=94 |issue= 6 |pages= 1636–41 |year= 2002 |pmid= 11920522 |doi=
*cite journal | author=Liu Y, Li J, Kim BO, "et al." |title=HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110. |journal=J. Biol. Chem. |volume=277 |issue= 26 |pages= 23854–63 |year= 2002 |pmid= 11959860 |doi= 10.1074/jbc.M200773200
*cite journal | author=Bell M, Schreiner S, Damianov A, "et al." |title=p110, a novel human U6 snRNP protein and U4/U6 snRNP recycling factor. |journal=EMBO J. |volume=21 |issue= 11 |pages= 2724–35 |year= 2002 |pmid= 12032085 |doi= 10.1093/emboj/21.11.2724
*cite journal | author=Nottrott S, Urlaub H, Lührmann R |title=Hierarchical, clustered protein interactions with U4/U6 snRNA: a biochemical role for U4/U6 proteins. |journal=EMBO J. |volume=21 |issue= 20 |pages= 5527–38 |year= 2002 |pmid= 12374753 |doi=
*cite journal | author=Nakayama M, Kikuno R, Ohara O |title=Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs. |journal=Genome Res. |volume=12 |issue= 11 |pages= 1773–84 |year= 2003 |pmid= 12421765 |doi= 10.1101/gr.406902
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Stanĕk D, Rader SD, Klingauf M, Neugebauer KM |title=Targeting of U4/U6 small nuclear RNP assembly factor SART3/p110 to Cajal bodies. |journal=J. Cell Biol. |volume=160 |issue= 4 |pages= 505–16 |year= 2003 |pmid= 12578909 |doi= 10.1083/jcb.200210087
*cite journal | author=Damianov A, Schreiner S, Bindereif A |title=Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP. |journal=Mol. Cell. Biol. |volume=24 |issue= 4 |pages= 1700–8 |year= 2004 |pmid= 14749385 |doi=
*cite journal | author=Liu Y, Kim BO, Kao C, "et al." |title=Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 21766–73 |year= 2004 |pmid= 15031286 |doi= 10.1074/jbc.M314321200
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Medenbach J, Schreiner S, Liu S, "et al." |title=Human U4/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling. |journal=Mol. Cell. Biol. |volume=24 |issue= 17 |pages= 7392–401 |year= 2004 |pmid= 15314151 |doi= 10.1128/MCB.24.17.7392-7401.2004
*cite journal | author=Stanĕk D, Neugebauer KM |title=Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer. |journal=J. Cell Biol. |volume=166 |issue= 7 |pages= 1015–25 |year= 2004 |pmid= 15452143 |doi= 10.1083/jcb.200405160
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504

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