Flavin containing amine oxidoreductase

Pfam_box
Symbol = Amino_oxidase
Name = Flavin containing amine oxidoreductase


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caption =
Pfam= PF01593
InterPro= IPR002937
SMART=
PROSITE = PDOC00755
SCOP = 1b37
TCDB =
OPM family= 128
OPM protein= 1sez
PDB=PDB3|1tdoA:61-499 PDB3|1tdkA:61-499 PDB3|1tdnA:61-499PDB3|1reoA:61-499 PDB3|1f8sD:61-499 PDB3|1f8rD:61-499PDB3|1sezA:23-490 PDB3|1z6lA:18-504 PDB3|1yy5B:18-504PDB3|1xpqD:18-504 PDB3|1rsgB:18-504 PDB3|1yvvB:12-62PDB3|2babA:16-60 PDB3|2bacA:16-60 PDB3|2b9xA:16-60PDB3|2b9wA:16-60 PDB3|2b9yA:16-60 PDB3|2ba9A:16-60PDB3|1h86B:42-483 PDB3|1b5qB:42-483 PDB3|1h83B:42-483PDB3|1h84C:42-483 PDB3|1b37C:42-483 PDB3|1h81A:42-483PDB3|1h82B:42-483 PDB3|1o5wC:23-460 PDB3|1ojdF:14-451PDB3|2bk3B:14-451 PDB3|2c64A:14-451 PDB3|2bk5A:14-451PDB3|2c67B:14-451 PDB3|1s2yA:14-451 PDB3|2bybB:14-451PDB3|1ojcB:14-451 PDB3|2bk4B:14-451 PDB3|2c66A:14-451PDB3|1s3bA:14-451 PDB3|1s2qA:14-451 PDB3|1ojaA:14-451PDB3|1ojbA:14-451 PDB3|1gosA:14-451 PDB3|2c65A:14-451PDB3|1oj9B:14-451 PDB3|1h8rA:14-451 PDB3|1s3eA:14-451PDB3|2bxrA:23-460 PDB3|2bxsB:23-460 PDB3|1h8qA:23-460

Flavin containing amine oxidoreductases are a family of various amine oxidases, including maize polyamine oxidase (PAO)cite journal |author=Schinina ME, Mariottini P, Tavladoraki P, Cecconi F, Manera F, Rea G, Federico R, Angelini R, DiAgostino S |title=Maize polyamine oxidase: primary structure from protein and cDNA sequencing |journal=FEBS Lett. |volume=426 |issue=1 |pages=62–66 |year=1998 |pmid=9598979 |doi=10.1016/S0014-5793(98)00311-1] , L-amino acid oxidases (LAO) and various flavin containing monoamine oxidases (MAO). The aligned region includes the flavin binding site of these enzymes. In vertebrates MAO plays an important role in regulating the intracellular levels of amines via their oxidation; these include various neurotransmitters, neurotoxins and trace aminescite journal |author=Tsugeno Y, Ito A |title=A key amino acid responsible for substrate selectivity of monoamine oxidase A and B |journal=J. Biol. Chem. |volume=272 |issue=22 |pages=14033–14036 |year=1997 |pmid=9162023 |doi=10.1074/jbc.272.22.14033] . In lower eukaryotes such as aspergillus and in bacteria the main role of amine oxidases is to provide a source of ammoniumcite journal |author=Lerch K, Schilling B |title=Cloning, sequencing and heterologous expression of the monoamine oxidase gene from Aspergillus niger |journal=Mol. Gen. Genet. |volume=247 |issue=4 |pages=430–438 |year=1995 |pmid=7770050 |doi=10.1007/BF00293144] . PAOs in plants, bacteria and protozoa oxidise spermidine and spermine to an aminobutyral, diaminopropane and hydrogen peroxide and are involved in the catabolism of polyamines. Other members of this family include tryptophan 2-monooxygenase, putrescine oxidase, corticosteroid binding proteins and antibacterial glycoproteins.

Human proteins containing this domain

AOF1; AOF2; IL4I1; MAOA; MAOB; PAOX; PPOX; SMOX;

References