- N-acylmannosamine kinase
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N-acylmannosamine kinase Identifiers EC number 2.7.1.60 CAS number 9027-53-6 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a N-acylmannosamine kinase (EC 2.7.1.60) is an enzyme that catalyzes the chemical reaction
- ATP + N-acyl-D-mannosamine
ADP + N-acyl-D-mannosamine 6-phosphate
Thus, the two substrates of this enzyme are ATP and N-acyl-D-mannosamine, whereas its two products are ADP and N-acyl-D-mannosamine 6-phosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:N-acyl-D-mannosamine 6-phosphotransferase. Other names in common use include acylmannosamine kinase (phosphorylating), acetylamidodeoxymannokinase, acetylmannosamine kinase, acylaminodeoxymannokinase, acylmannosamine kinase, N-acyl-D-mannosamine kinase, N-acetylmannosamine kinase, and ATP:N-acetylmannosamine 6-phosphotransferase. This enzyme participates in aminosugars metabolism.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2AA4.
References
- Banerjee S, Ghosh S (1969). "Purification and properties of N-acetylmannosamine kinase from Salmonella typhimurium". Eur. J. Biochem. 8 (2): 200–6. doi:10.1111/j.1432-1033.1969.tb00515.x. PMID 4889177.
- GHOSH S, ROSEMAN S (1961). "Enzymatic phosphorylation of N-acetyl-D-mannosamine". Proc. Natl. Acad. Sci. U. S. A. 47 (7): 955–8. doi:10.1073/pnas.47.7.955. PMC 221308. PMID 13704957. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=221308.
- Kundig W, Ghosh S, Roseman S (1966). "The sialic acids. VII. N-acyl-D-mannosamine kinase from rat liver". J. Biol. Chem. 241 (23): 5619–26. PMID 5928201.
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