- Mannose-1-phosphate guanylyltransferase (GDP)
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mannose-1-phosphate guanylyltransferase (GDP) Identifiers EC number 2.7.7.22 CAS number 9026-31-7 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a mannose-1-phosphate guanylyltransferase (GDP) (EC 2.7.7.22) is an enzyme that catalyzes the chemical reaction
- GDP + alpha-D-mannose 1-phosphate
phosphate + GDP-mannose
Thus, the two substrates of this enzyme are GDP and alpha-D-mannose 1-phosphate, whereas its two products are phosphate and GDP-mannose.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is GDP:alpha-D-mannose-1-phosphate guanylyltransferase. This enzyme participates in fructose and mannose metabolism.
Other common names
- GDP mannose phosphorylase
- Mannose 1-phosphate (guanosine diphosphate) guanylyltransferase
- GDP mannose phosphorylase
- GDP-mannose 1-phosphate guanylyltransferase
- Guanosine diphosphate-mannose 1-phosphate guanylyltransferase
- Guanosine diphosphomannose phosphorylase
- Mannose 1-phosphate guanylyltransferase
- GDP:D-mannose-1-phosphate guanylyltransferase
References
- CARMINATTI H, CABIB E (1961). "Phosphorolysis of the pyrophosphate bond of some nucleotides". Biochim. Biophys. Acta. 53 (2): 417–9. doi:10.1016/0006-3002(61)90458-9. PMID 13876695.
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