Ceramide kinase

ceramide kinase
Identifiers
EC number	2.7.1.138
CAS number	123175-68-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a ceramide kinase (EC 2.7.1.138) is an enzyme that catalyzes the chemical reaction

ATP + ceramide $\rightleftharpoons$ ADP + ceramide 1-phosphate

Thus, the two substrates of this enzyme are ATP and ceramide, whereas its two products are ADP and ceramide 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:ceramide 1-phosphotransferase. This enzyme is also called acylsphingosine kinase. This enzyme participates in sphingolipid metabolism.

References

• Bajjalieh SM, Martin TF, Floor E (1989). "Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles". J. Biol. Chem. 264 (24): 14354–60. PMID 2547795. 

This enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Enzyme stubs EC 2.7.1 Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Поможем решить контрольную работу Luis de Cortázar Ottawa Rapidz Look at other dictionaries: Ceramide glucosyltransferase — (or glucosylceramide synthase) is a glucosyltransferase enzyme involved in the production of glucosylceramide. It is classified under EC 2.4.1.80. It is inhibited by miglustat. See also Glucosylceramide External links MeSH… …   Wikipedia Sphingosine kinase — protein Name= sphingosine kinase 1 caption= width= HGNCid=11240 Symbol=SPHK1 AltSymbols= EntrezGene=8877 OMIM=603730 RefSeq=NM 182965 UniProt=Q9NYA1 PDB= ECnumber= Chromosome=17 Arm=q Band=25.2 LocusSupplementaryData=protein Name=sphingosine… …   Wikipedia CERK — Ceramide kinase, also known as CERK, is a human gene.cite web | title = Entrez Gene: CERK ceramide kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=64781| accessdate = ] PBB Summary section title =… …   Wikipedia List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia AGK (gene) — Acylglycerol kinase, also known as AGK, is a human gene.cite web | title = Entrez Gene: AGK acylglycerol kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=55750| accessdate = ] PBB Summary section… …   Wikipedia Metabolism — Cell metabolism redirects here. For the journal, see Cell Metabolism. Structure of adenosine triphosphate, a central intermediate in energy metabolism Metabolism (from Greek: μεταβολή metabolē , change or Greek: μεταβολισμός metabolismos,… …   Wikipedia Lipid — Structures of some common lipids. At the top are oleic acid[1] and cholesterol.[2] The middle structure is a triglyceride composed of oleoyl, stearoyl, and palmitoyl chains at …   Wikipedia COL4A3BP — Collagen, type IV, alpha 3 (Goodpasture antigen) binding protein, also known as COL4A3BP, is a human gene.cite web | title = Entrez Gene: COL4A3BP collagen, type IV, alpha 3 (Goodpasture antigen) binding protein| url =… …   Wikipedia Ceramidase — is an enzyme which cleaves fatty acids from ceramide, producing sphingosine (SPH) which in turn is phosphorylated by a sphingosine kinase to form sphingosine 1 phosphate (S1P).[1] Contents 1 Function 2 Clinical significance …   Wikipedia LIPIDES — Le terme de lipides recouvre un ensemble de composés naturels qui ont la propriété d’être insolubles dans l’eau, en raison de la présence, dans leurs molécules, de longues chaînes hydrocarbonées d’acides gras ou de dérivés. À l’inverse, ils sont… …   Encyclopédie Universelle 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”