6-phosphofructo-2-kinase

In enzymology, a 6-phosphofructo-2-kinase (EC number|2.7.1.105) is an enzyme that catalyzes the chemical reaction

:ATP + beta-D-fructose 6-phosphate $ightleftharpoons$ ADP + beta-D-fructose 2,6-bisphosphate

Thus, the two substrates of this enzyme are ATP and beta-D-fructose 6-phosphate, whereas its two products are ADP and beta-D-fructose 2,6-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:beta-D-fructose-6-phosphate 2-phosphotransferase. Other names in common use include phosphofructokinase 2, 6-phosphofructose 2-kinase, 6-phosphofructo-2-kinase (phosphorylating), fructose 6-phosphate 2-kinase, and ATP:D-fructose-6-phosphate 2-phosphotransferase. This enzyme participates in fructose and mannose metabolism.

tructural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1BIF, PDB link|1K6M, PDB link|2AXN, PDB link|2BIF, PDB link|2DWO, PDB link|2DWP, PDB link|2I1V, and PDB link|3BIF.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|78689-77-7."

Gene Ontology (GO) codes