- Quaternium-15
-
Cis/trans-Quaternium-15 
Identifiers CAS number 4080-31-3 
PubChem 6435993 ChemSpider 4940676 UNII E40U03LEM0 Jmol-3D images Image 1 - [Cl-].Cl[C@H]=CC[N+]13CN2CN(CN(C1)C2)C3
- InChI=1S/C9H16ClN4.ClH/c10-2-1-3-14-7-11-4-12(8-14)6-13(5-11)9-14;/h1-2H,3-9H2;1H/q+1;/p-1/b2-1-;
Key: UKHVLWKBNNSRRR-ODZAUARKSA-M
InChI=1/C9H16ClN4.ClH/c10-2-1-3-14-7-11-4-12(8-14)6-13(5-11)9-14;/h1-2H,3-9H2;1H/q+1;/p-1/b2-1-;
Key: UKHVLWKBNNSRRR-NTXAGKCLBR
Properties Molecular formula C9H16Cl2N4 Molar mass 251.16 g mol−1 Hazards MSDS External MSDS EU classification Harmful XN; Highly flammable F+ R-phrases R11 R22 S-phrases S16 S36 
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Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)Infobox references Quaternium-15 is a quaternary ammonium salt used as a preservative in many cosmetics and industrial substances. It acts as a formaldehyde releaser. It can cause contact dermatitis, a symptom of an allergic reaction, especially in those with sensitive skin, on an infant's skin, or on sensitive areas such as the genitals.
It can be found under a variety of names, including: Dowicil 75; Dowicil 100; Dowco 184; Dowicide Q; 1-(3-Chloroallyl)-3,5,7-triaza-1-azoniaadamantane chloride; N-(3-chloroallyl) hexaminium chloride; hexamethylenetetramine chloroallyl chloride; 3,5,7-triaza-1-azoniaadamantane; 1-(3-chloroallyl)-chloride.
Contents
Safety concerns
Quaternium-15 is an allergen, and can cause contact dermatitis in susceptible individuals.[1] Many of those with an allergy to quaternium-15 are also allergic to formaldehyde. Allergic sensitivity to quaternium-15 can be detected using a patch test.[2] It is the single most often found cause of allergic contact dermatitis of the hands (16.5% in 959 cases).[3]
References
- ^ Cahill J, Nixon R. Allergic contact dermatitis to quaternium 15 in a moisturizing lotion. Australasia J Dermatol. 2005 Nov;46(4):284-5. PMID 16197434
- ^ New Zealand Dermatological Society. "Quaternium-15 contact allergy". DermNet NZ. http://dermnetnz.org/dermatitis/quaternium-allergy.html. Retrieved 2007-05-31.
- ^ E. Warshaw, et al. Contact dermatitis of the hands: Cross-sectional analyses of North American Contact Dermatitis Group Data, 1994-2004. Journal of the American Academy of Dermatology, Volume 57, Issue 2, Pages 301-314
See also
External links
- DermNet dermatitis/quaternium-allergy
- Record in the Household Products Database of NLM
- Occupational Hazards - Quaternium-15
Categories:- Cosmetics chemicals
- Preservatives
- Quaternary ammonium compounds
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