Outer membrane efflux proteins

Outer membrane efflux protein
Identifiers
Symbol	OEP
Pfam	PF02321
InterPro	IPR003423
SCOP	1ek9
TCDB	2.A.6
OPM family	34
OPM protein	1yc9
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

Outer membrane efflux protein family form trimeric channels that allow export of a variety of substrates in Gram negative bacteria. Each member of this family is composed of two repeats. The trimeric channel is composed of a 12 stranded all beta sheet barrel that spans the outer membrane, and a long all helical barrel that spans the periplasm.

Examples include the Escherichia coli TolC outer membrane protein, which is required for proper expression of outer membrane protein genes; the Rhizobium nodulation protein; and the Pseudomonas FusA protein, which is involved in resistance to fusaric acid.

Subfamilies

• Type I secretion outer membrane protein, TolC IPR010130
• RND efflux system, outer membrane lipoprotein, NodT IPR010131

References

• Alignment and structure prediction of divergent protein families: periplasmic and outer membrane proteins of bacterial efflux pumps. Johnson JM, Church GM; J Mol Biol 1999;287:695-715. PubMed

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