N-acetylneuraminate 7-O(or 9-O)-acetyltransferase

N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
N-acetylneuraminate 7-O(or 9-O)-acetyltransferase
Identifiers
EC number 2.3.1.45
CAS number 9054-50-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-acetylneuraminate 7-O(or 9-O)-acetyltransferase (EC 2.3.1.45) is an enzyme that catalyzes the chemical reaction

acetyl-CoA + N-acetylneuraminate \rightleftharpoons CoA + N-acetyl-7-O(or 9-O)-acetylneuraminate

Thus, the two substrates of this enzyme are acetyl-CoA and N-acetylneuraminate, whereas its 3 products are CoA, N-acetyl-7-O-acetylneuraminate, and N-acetyl-9-O-acetylneuraminate.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acetyl-CoA:N-acetylneuraminate 7-O(or 9-O)-acetyltransferase. Other names in common use include N-acetylneuraminate 7(8)-O-acetyltransferase, sialate O-acetyltransferase, N-acetylneuraminate 7,8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-7- or 8-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-7- and/or 8-O-acetyltransferase, glycoprotein 7(9)-O-acetyltransferase, acetyl-CoA:N-acetylneuraminate-9(7)-O-acetyltransferase, N-acetylneuraminate O7-(or O9-)acetyltransferase, and acetyl-CoA:N-acetylneuraminate-9(or 7)-O-acetyltransferase.

References

  • Schauer R (1970). "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. I. Incorporation of (14C) acetate into sections of the submaxillary salivary gland of ox and horse]". Hoppe. Seylers. Z. Physiol. Chem. 351 (5): 595–602. PMID 5446640. 
  • Schauer R (1970). "[Biosynthesis of N-acetyl-O-acetylneuraminic acids. II. Substrate and intracellular localization of bovine acetyl-coenzyme A: N-acetylneuraminate-7- and 8-O-acetyltransferase]". Hoppe. Seylers. Z. Physiol. Chem. 351 (6): 749–58. doi:10.1515/bchm2.1970.351.1.749. PMID 5425947. 
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