Deacetyl-(citrate-(pro-3S)-lyase) S-acetyltransferase

Deacetyl-(citrate-(pro-3S)-lyase) S-acetyltransferase
deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase
Identifiers
EC number 2.3.1.49
CAS number 42616-18-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a deacetyl-[citrate-(pro-3S)-lyase] S-acetyltransferase (EC 2.3.1.49) is an enzyme that catalyzes the chemical reaction

S-acetylphosphopantetheine + deacetyl-[citrate-oxaloacetate-lyase((pro-3S)-CH2COO-->acetate)] \rightleftharpoons phosphopantetheine + [citrate-oxaloacetate-lyase((pro-3S)-CH2COO-->acetate)]

Thus, the two substrates of this enzyme are S-acetylphosphopantetheine and [[deacetyl-[citrate-oxaloacetate-lyase((pro-3S)-CH2COO-->acetate)]]], whereas its two products are phosphopantetheine and [[citrate-oxaloacetate-lyase((pro-3S)-CH2COO-->acetate)]].

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is S-acetylphosphopantetheine:deacetyl-[citrate-oxaloacetate-lyase((pro -3S)-CH2COO-->acetate)] S-acetyltransferase. Other names in common use include S-acetyl phosphopantetheine:deacetyl citrate lyase, S-acetyltransferase, and deacetyl-[citrate-(pro-3S)-lyase] acetyltransferase.

References

  • Singh M, Bottger B, Stewart C, Brooks GC, Srere PA (1973). "S-acetyl phosphopantetheine: deacetyl citrate lyase S-acetyl transferase from Klebsiella aerogenes". Biochem. Biophys. Res. Commun. 53 (1): 1–9. doi:10.1016/0006-291X(73)91392-2. PMID 4741546. 
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