Phosphopantetheine

Phosphopantetheine

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ImageFile = Phosphopantetheine.svg
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Section1 = Chembox Identifiers
CASNo = 2226-71-3
PubChem = 987
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MeSHName = phosphopantetheine
Section2 = Chembox Properties
Formula = C11H23N2O7PS
MolarMass = 358.349 g/mol
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4'-Phosphopantetheine is an essential prosthetic group of acyl carrier protein (ACP) and peptidyl carrier proteins (PCP) and aryl carrier proteins (ArCP) derived from Coenzyme A.

Functions

Phosphopantetheine fulfils two demands.
* Firstly, the intermediates remain covalently linked to the synthases (or synthetases) in an energy-rich thiol ester linkage.
* Secondly, the flexibility and length of phosphopantetheine chain (approximately 2 nm) allows the covalently tethered intermediates to have access to spatially distinct enzyme active sites.

ee also

* pantothenic acid
* fatty acid synthase


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