Dihydrobiopterin reductase

Dihydrobiopterin reductase

Dihydrobiopterin is a compound produced in the synthesis of dopamine, norepinephrine and epinephrine through production of the intermediate 3,4-dihydroxy phenylalanine, also known as dopa. Phenylalanine is converted into dopa using tetrahydrobiopterin releasing dihydrobiopterin and water, which is then converted back into tetrahydrobiopterin using the NADPH-dependent enzyme dihydrobiopterin reductase. This enzyme is sometimes defective in patients with phenylketonuria, and is treated in the same fashion, with tyrosine supplements and a controlled diet which is lacking in phenylalanine.[1]

See also

References

  1. ^ Pawlina, Wojciech; Ross, Michael W. (2006). Histology: a text and atlas: with correlated cell and molecular biology. Philadelphia: Lippincott Wiliams & Wilkins. ISBN 0-7817-5056-3. 

Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • Dihydrobiopterin — IUPAC name 2 Amino 6 (1,2 dihydroxypropyl) 7,8 dihydro 1H pteridin 4 one …   Wikipedia

  • dihydrobiopterin — Precursor to tetrahydrobiopterin, a required cofactor for a number of enzymes, including the biosynthesis of l tyrosine; the inability to synthesize d. can result in a form of malignant hyperphenylalaninemia. d. reductase SYN: dihydropteridine… …   Medical dictionary

  • dihydropteridine reductase — An enzyme that catalyzes the reversible formation of tetrahydrobiopterin from dihydrobiopterine using NADPH; a deficiency of this enzyme can result in malignant hyperphenylalaninemia. SYN: dihydrobiopterin reductase …   Medical dictionary

  • Sepiapterin reductase — In enzymology, a sepiapterin reductase (EC number|1.1.1.153) is an enzyme that catalyzes the chemical reaction:7,8 dihydrobiopterin + NADP+ ightleftharpoons sepiapterin + NADPH + H+Thus, the two substrates of this enzyme are 7,8 dihydrobiopterin… …   Wikipedia

  • 67-dihydropteridine reductase — (DHPR) 6,7 di·hy·dro·pter·i·dine re·duc·tase (DHPR) (di hi″dro terґĭ dēn re dukґtās) [EC 1.5.1.34] an enzyme of the oxidoreductase class that catalyzes the NAD(P)H dependent reduction of dihydrobiopterin to regenerate… …   Medical dictionary

  • Nitric oxide synthase — Identifiers EC number 1.14.13.39 CAS number 125978 95 2 …   Wikipedia

  • SPR (gene) — Sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase), also known as SPR, is a human gene.cite web | title = Entrez Gene: SPR sepiapterin reductase (7,8 dihydrobiopterin:NADP+ oxidoreductase)| url =… …   Wikipedia

  • Sepiapterin-Reduktase — Bändermodell des SPR Dimers des Menschen nach …   Deutsch Wikipedia

  • Phenylalanine hydroxylase — predicted 3D structure of phenylalanine hydroxylase …   Wikipedia

  • Sepiapterin — Strukturformel Allgemeines Name Sepiapterin Andere Namen …   Deutsch Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”