N-carbamoylsarcosine amidase

N-carbamoylsarcosine amidase
N-carbamoylsarcosine amidase
Identifiers
EC number 3.5.1.59
CAS number 92767-52-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-carbamoylsarcosine amidase (EC 3.5.1.59) is an enzyme that catalyzes the chemical reaction

N-carbamoylsarcosine + H2O \rightleftharpoons sarcosine + CO2 + NH3

Thus, the two substrates of this enzyme are N-carbamoylsarcosine and H2O, whereas its 3 products are sarcosine, CO2, and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-carbamoylsarcosine amidohydrolase. This enzyme is also called carbamoylsarcosine amidase. This enzyme participates in arginine and proline metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1NBA.

References

  • Deeg R, Roeder A, Siedel J, Gauhl H and Ziegenhorn J (1984). "Process and reagent for the determination of N-carbamoylsarcosine with the use of a new enzyme". Chem. Abstr. 101: 18751. 
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