N-methylhydantoinase (ATP-hydrolysing)

N-methylhydantoinase (ATP-hydrolysing)
N-methylhydantoinase (ATP-hydrolyzing)
Identifiers
EC number 3.5.2.14
CAS number 100785-00-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-methylhydantoinase (ATP-hydrolysing) (EC 3.5.2.14) is an enzyme that catalyzes the chemical reaction

ATP + N-methylimidazolidine-2,4-dione + 2 H2O \rightleftharpoons ADP + phosphate + N-carbamoylsarcosine

The 3 substrates of this enzyme are ATP, N-methylimidazolidine-2,4-dione, and H2O, whereas its 3 products are ADP, phosphate, and N-carbamoylsarcosine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is N-methylimidazolidine-2,4-dione amidohydrolase (ATP-hydrolysing). Other names in common use include N-methylhydantoin amidohydrolase, methylhydantoin amidase, N-methylhydantoin hydrolase, and N-methylhydantoinase. This enzyme participates in arginine and proline metabolism.

References

  • Kim JM, Shimizu S, Yamada H (1987). "Amidohydrolysis of N-methylhydantoin coupled with ATP hydrolysis". Biochem. Biophys. Res. Commun. 142 (3): 1006–12. doi:10.1016/0006-291X(87)91514-2. PMID 3827889. 
Stub icon This hydrolase article is a stub. You can help Wikipedia by expanding it.