Peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase

In enzymology, a peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase (EC number|3.5.1.52) is an enzyme that catalyzes a chemical reaction that cleaves a N₄-(acetyl-beta-D-glucosaminyl)asparagine residue in which the glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue.

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-nitrogen bonds other than peptide bonds in linear amides. The systematic name of this enzyme class is N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase. Other names in common use include glycopeptide N-glycosidase, glycopeptidase, N-oligosaccharide glycopeptidase, N-glycanase, Jack-bean glycopeptidase, PNGase A, and PNGase F.

tructural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1PGS, PDB link|1PNF, PDB link|1PNG, PDB link|1X3W, PDB link|1X3Z, PDB link|2D5U, PDB link|2F4M, PDB link|2F4O, PDB link|2G9F, PDB link|2G9G, PDB link|2HPJ, PDB link|2HPL, and PDB link|2I74.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|83534-39-8."

Gene Ontology (GO) codes