N-acetylglucosamine deacetylase

N-acetylglucosamine deacetylase
N-acetylglucosamine deacetylase
Identifiers
EC number 3.5.1.33
CAS number 9012-32-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-acetylglucosamine deacetylase (EC 3.5.1.33) is an enzyme that catalyzes the chemical reaction

N-acetyl-D-glucosamine + H2O \rightleftharpoons D-glucosamine + acetate

Thus, the two substrates of this enzyme are N-acetyl-D-glucosamine and H2O, whereas its two products are D-glucosamine and acetate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-acetyl-D-glucosamine amidohydrolase. Other names in common use include acetylaminodeoxyglucose acetylhydrolase, and N-acetyl-D-glucosaminyl N-deacetylase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2C1G and 2C1I.

References

  • Roseman S (1957). "Glucosamine metabolism. I. N-Acetylglucosamine deacetylase". J. Biol. Chem. 226: 115–123. PMID 13428742. 
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