N-acetylglucosamine-6-phosphate deacetylase

N-acetylglucosamine-6-phosphate deacetylase
Identifiers
EC number	3.5.1.25
CAS number	9027-50-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a N-acetylglucosamine-6-phosphate deacetylase (EC 3.5.1.25) is an enzyme that catalyzes the chemical reaction

N-acetyl-D-glucosamine 6-phosphate + H₂O $\rightleftharpoons$ D-glucosamine 6-phosphate + acetate

Thus, the two substrates of this enzyme are N-acetyl-D-glucosamine 6-phosphate and H₂O, whereas its two products are D-glucosamine 6-phosphate and acetate.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is N-acetyl-D-glucosamine-6-phosphate amidohydrolase. Other names in common use include acetylglucosamine phosphate deacetylase, acetylaminodeoxyglucosephosphate acetylhydrolase, and 2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, 6 structures have been solved for this class of enzymes, with PDB accession codes 1O12, 1UN7, 1YMY, 1YRR, 2P50, and 2P53.

References

• White RJ, Pasternak CA (1967). "The purification and properties of N-acetylglucosamine 6-phosphate deacetylase from Escherichia coli". Biochem. J. 105 (1): 121–5. PMC 1198282. PMID 4861885. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1198282. 
• Yamano N, Matsushita Y, Kamada Y, Fujishima S, Arita M (1996). "Purification and characterization of N-acetylglucosamine 6-phosphate deacetylase with activity against N-acetylglucosamine from Vibrio cholerae non-O1". Biosci. Biotechnol. Biochem. 60 (8): 1320–3. doi:10.1271/bbb.60.1320. PMID 8987551. 

This hydrolase article is a stub. You can help Wikipedia by expanding it.v · Categories: Hydrolase stubs EC 3.5.1 Enzymes of known structure Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Brad Wanchulak Megullia Dotata Look at other dictionaries: Hydrolase — Cristal de lysozyme Les hydrolases constituent une classe d enzymes qui catalysent les réactions d hydrolyse de molécules suivant la réaction générale : R R + H2O ⇌ R OH + R H On y trouve par exemple les estérases, qui hydrolysent les …   Wikipédia en Français List of EC numbers (EC 3) — This list contains a list of EC numbers for the third group, EC 3, hydrolases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 3.1: Acting on Ester BondsEC… …   Wikipedia EC 3.5 — Le groupe EC3.5 rassemble des enzymes appartenant à la famille des hydrolases. Elles ont pour particularité de catalyser des réactions d hydrolyse dans des molécules possédant un carbone et un azote liés par liaison simple, double ou triple. À la …   Wikipédia en Français NAGK — N acetylglucosamine kinase PDB rendering based on 2ch5 …   Wikipedia EC 3.1 — Le groupe EC3.1 est un groupe d hydrolases rassemblant les estérases, c est à dire les enzymes catalysant la réaction générale : R O R + H2O ⇌ R OH + R OH où R représente un acide quelconque et R son substrat. En fonction du milieu, l ester… …   Wikipédia en Français 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”