DCTP deaminase

In enzymology, a dCTP deaminase (EC number|3.5.4.13) is an enzyme that catalyzes the chemical reaction

:dCTP + H₂O $ightleftharpoons$ dUTP + NH₃

Thus, the two substrates of this enzyme are dCTP and H₂O, whereas its two products are dUTP and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase. Other names in common use include deoxycytidine triphosphate deaminase, and 5-methyl-dCTP deaminase. This enzyme participates in pyrimidine metabolism.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1OGH, PDB link|1PKH, PDB link|1PKJ, PDB link|1PKK, PDB link|1XS1, PDB link|1XS4, PDB link|1XS6, PDB link|2J4H, and PDB link|2J4Q.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37289-18-2."

Gene Ontology (GO) codes