DCTP deaminase (dUMP-forming)

In enzymology, a dCTP deaminase (dUMP-forming) (EC number|3.5.4.30) is an enzyme that catalyzes the chemical reaction

:dCTP + 2 H₂O $ightleftharpoons$ dUMP + diphosphate + NH₃

Thus, the two substrates of this enzyme are dCTP and H₂O, whereas its 3 products are dUMP, diphosphate, and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase (dUMP-forming). This enzyme participates in pyrimidine metabolism.

tructural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2HXB, PDB link|2HXD, and PDB link|2HXE.

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