- dCTP deaminase (dUMP-forming)
DCTP deaminase (dUMP-forming) Identifiers EC number 22.214.171.124 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Search PMC articles PubMed articles
In enzymology, a dCTP deaminase (dUMP-forming) (EC 126.96.36.199) is an enzyme that catalyzes the chemical reaction
- dCTP + 2 H2O dUMP + diphosphate + NH3
Thus, the two substrates of this enzyme are dCTP and H2O, whereas its 3 products are dUMP, diphosphate, and NH3.
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is dCTP aminohydrolase (dUMP-forming). This enzyme participates in pyrimidine metabolism.
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2HXB, 2HXD, and 2HXE.
- Li H, Xu H, Graham DE, White RH (2003). "The Methanococcus jannaschii dCTP deaminase is a bifunctional deaminase and diphosphatase". J. Biol. Chem. 278 (13): 11100–6. doi:10.1074/jbc.M212460200. PMID 12538648.
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