dCTP diphosphatase

dCTP diphosphatase
dCTP diphosphatase
Identifiers
EC number 3.6.1.12
CAS number 9024-87-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a dCTP diphosphatase (EC 3.6.1.12) is an enzyme that catalyzes the chemical reaction

dCTP + H2O \rightleftharpoons dCMP + diphosphate

Thus, the two substrates of this enzyme are dCTP and H2O, whereas its two products are dCMP and diphosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is dCTP nucleotidohydrolase. Other names in common use include deoxycytidine-triphosphatase, dCTPase, dCTP pyrophosphatase, deoxycytidine triphosphatase, deoxy-CTPase, and dCTPase. This enzyme participates in pyrimidine metabolism.

References

  • Zimmerman SB and Kornberg A (1961). "Deoxycytidine di- and triphosphate cleavage by an enzyme formed in bacteriophage-infected Escherichia coli". J. Biol. Chem. 236: 1480–1486. PMID 13788541.