Aspartate-ammonia ligase

In enzymology, an aspartate-ammonia ligase (EC number|6.3.1.1) is an enzyme that catalyzes the chemical reaction

:ATP + L-aspartate + NH₃ $ightleftharpoons$ AMP + diphosphate + L-asparagine

The 3 substrates of this enzyme are ATP, L-aspartate, and NH₃, whereas its 3 products are AMP, diphosphate, and L-asparagine.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-ammonia (or amine) ligases (amide synthases). The systematic name of this enzyme class is L-aspartate:ammonia ligase (AMP-forming). Other names in common use include asparagine synthetase, and L-asparagine synthetase. This enzyme participates in 3 metabolic pathways: alanine and aspartate metabolism, cyanoamino acid metabolism, and nitrogen metabolism.

tructural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|11AS and PDB link|12AS.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9023-69-2."

Gene Ontology (GO) codes