4-hydroxy-2-oxoglutarate aldolase
- 4-hydroxy-2-oxoglutarate aldolase
In enzymology, a 4-hydroxy-2-oxoglutarate aldolase (EC number|4.1.3.16) is an enzyme that catalyzes the chemical reaction
:4-hydroxy-2-oxoglutarate pyruvate + glyoxylate
Hence, this enzyme has one substrate, 4-hydroxy-2-oxoglutarate, and two products, pyruvate and glyoxylate.
This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming). Other names in common use include 2-oxo-4-hydroxyglutarate aldolase, hydroxyketoglutaric aldolase, 4-hydroxy-2-ketoglutaric aldolase, 2-keto-4-hydroxyglutaric aldolase, 4-hydroxy-2-ketoglutarate aldolase, 2-keto-4-hydroxyglutarate aldolase, 2-oxo-4-hydroxyglutaric aldolase, DL-4-hydroxy-2-ketoglutarate aldolase, hydroxyketoglutarate aldolase, 2-keto-4-hydroxybutyrate aldolase, and 4-hydroxy-2-oxoglutarate glyoxylate-lyase. This enzyme participates in arginine and proline metabolism and glyoxylate and dicarboxylate metabolism.
tructural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes PDB link|1WAU and PDB link|2C0A.
References
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* Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 7, Academic Press, New York, 1972, p. 281-302.
External links
::"The CAS registry number for this enzyme class is CAS registry|9030-81-3."
Gene Ontology (GO) codes
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