- 4-hydroxy-4-methyl-2-oxoglutarate aldolase
In
enzymology , a 4-hydroxy-4-methyl-2-oxoglutarate aldolase (EC number|4.1.3.17) is anenzyme that catalyzes thechemical reaction :4-hydroxy-4-methyl-2-oxoglutarate 2 pyruvate
Hence, this enzyme has one substrate,
4-hydroxy-4-methyl-2-oxoglutarate , and one product,pyruvate .This enzyme belongs to the family of
lyase s, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming). Other names in common use include pyruvate aldolase, gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase, 4-hydroxy-4-methyl-2-ketoglutarate aldolase, and 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase. This enzyme participates inbenzoate degradation via hydroxylation andc5-branched dibasic acid metabolism .References
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* Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 7, Academic Press, New York, 1972, p. 281-302.External links
::"The
CAS registry number for this enzyme class is CAS registry|37290-65-6."Gene Ontology (GO) codes
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