4-hydroxy-4-methyl-2-oxoglutarate aldolase

4-hydroxy-4-methyl-2-oxoglutarate aldolase

In enzymology, a 4-hydroxy-4-methyl-2-oxoglutarate aldolase (EC number|4.1.3.17) is an enzyme that catalyzes the chemical reaction

:4-hydroxy-4-methyl-2-oxoglutarate ightleftharpoons 2 pyruvate

Hence, this enzyme has one substrate, 4-hydroxy-4-methyl-2-oxoglutarate, and one product, pyruvate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming). Other names in common use include pyruvate aldolase, gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase, 4-hydroxy-4-methyl-2-ketoglutarate aldolase, and 4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase. This enzyme participates in benzoate degradation via hydroxylation and c5-branched dibasic acid metabolism.

References

*
*
*
* Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 7, Academic Press, New York, 1972, p. 281-302.

External links

::"The CAS registry number for this enzyme class is CAS registry|37290-65-6."

Gene Ontology (GO) codes


Wikimedia Foundation. 2010.

Игры ⚽ Нужен реферат?

Look at other dictionaries:

  • List of EC numbers (EC 4) — This list contains a list of EC numbers for the fourth group, EC 4, lyases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 4.1: Carbon Carbon LyasesEC… …   Wikipedia

  • metabolism — /meuh tab euh liz euhm/, n. 1. Biol., Physiol. the sum of the physical and chemical processes in an organism by which its material substance is produced, maintained, and destroyed, and by which energy is made available. Cf. anabolism, catabolism …   Universalium

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”