Coenzyme-B sulfoethylthiotransferase

Coenzyme-B sulfoethylthiotransferase
coenzyme-B sulfoethylthiotransferase
Identifiers
EC number 2.8.4.1
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a coenzyme-B sulfoethylthiotransferase (EC 2.8.4.1) is an enzyme that catalyzes the chemical reaction

2-(methylthio)ethanesulfonate (methyl-CoM) + N-(7-mercaptoheptanoyl)threonine 3-O-phosphate (coenzyme B) \rightleftharpoons CoM-S-S-CoB + methane

Thus, the two substrates of this enzyme are 2-(methylthio)ethanesulfonate and N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, whereas its two products are CoM-S-S-CoB and methane.

This enzyme belongs to the family of transferases, specifically those transferring alkylthio groups. The systematic name of this enzyme class is 2-(methylthio)ethanesulfonate:N-(7-thioheptanoyl)-3-O-phosphothreoni ne S-(2-sulfoethyl)thiotransferase. Other names in common use include methyl-CoM reductase, and methyl coenzyme M reductase. This enzyme participates in folate biosynthesis.

References

  • Bobik TA, Olson KD, Noll KM, Wolfe RS (1987). "Evidence that the heterodisulfide of coenzyme M and 7-mercaptoheptanoylthreonine phosphate is a product of the methylreductase reaction in Methanobacterium". Biochem. Biophys. Res. Commun. 149 (2): 455–60. doi:10.1016/0006-291X(87)90389-5. PMID 3122735. 
  • Ellermann J, Hedderich R, Boecher R and Thauer RK (1988). "The final step in methane formation: investigations with highly purified methyl coenzyme M reductase component C from Methanobacterium thermoautotrophicum (strain Marburg)". Eur. J. Biochem. 184 (1): 63–68. doi:10.1111/j.1432-1033.1989.tb14990.x. PMID 2506016. 
  • Ermler U, Grabarse W, Shima S, Goubeaud M, Thauer RK (1997). "Crystal structure of methyl-coenzyme M reductase: the key enzyme of biological methane formation". Science. 278 (5342): 1457–62. doi:10.1126/science.278.5342.1457. PMID 9367957. 
  • Signor L, Knuppe C, Hug R, Schweizer B, Pfaltz A, Jaun B (2000). "Methane formation by reaction of a methyl thioether with a photo-excited nickel thiolate--a process mimicking methanogenesis in archaea". Chemistry. 6 (19): 3508–16. doi:10.1002/1521-3765(20001002)6:19<3508::AID-CHEM3508>3.3.CO;2-N. PMID 11072815. 


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