PIK3CG

Phosphoinositide-3-kinase, catalytic, gamma polypeptide
PDB rendering based on 17eu.
Available structures PDB 1E8Y, 1E8Z, 1HE8, 2A4Z, 2A5U, 2CHW, 2CHX, 2CHZ, 2V4L, 3CSF, 3CST, 3DBS, 3DPD, 3ENE, 3IBE, 3L08, 3L13, 3L16, 3L17, 3L54, 3LJ3, 3MJW, 3ML8, 3ML9, 3OAW
Identifiers
Symbols	PIK3CG; PI3CG; PI3K; PI3Kgamma; PIK3
External IDs	OMIM: 601232 MGI: 1353576 HomoloGene: 68269 GeneCards: PIK3CG Gene
EC number	2.7.1.153
Gene Ontology Molecular function • nucleotide binding • inositol or phosphatidylinositol kinase activity • protein binding • ATP binding • 1-phosphatidylinositol-3-kinase activity • phosphotransferase activity, alcohol group as acceptor • phosphatidylinositol-4,5-bisphosphate 3-kinase activity Cellular component • cytosol • cytosol • phosphatidylinositol 3-kinase complex Biological process • protein phosphorylation • G-protein coupled receptor protein signaling pathway • blood coagulation • platelet activation • negative regulation of apoptosis • phosphatidylinositol phosphorylation • phosphatidylinositol-mediated signaling Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	5294	30955
Ensembl	ENSG00000105851	ENSMUSG00000020573
UniProt	P48736	Q24LN5
RefSeq (mRNA)	NM_002649	NM_020272
RefSeq (protein)	NP_002640	NP_064668
Location (UCSC)	Chr 7: 106.51 – 106.55 Mb	Chr 12: 32.86 – 32.89 Mb
PubMed search	[1]	[2]

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform is an enzyme that in humans is encoded by the PIK3CG gene.

This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias.^[1]

Interactions

PIK3CG has been shown to interact with PIK3CD,^[2] KRAS,^[3] PIK3R5^[4] and BCR gene.^[5][6][7]

See also

• Class I PI 3-kinases
• p87PIKAP

References

1. ^ "Entrez Gene: PIK3CG phosphoinositide-3-kinase, catalytic, gamma polypeptide". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5294. 
2. ^ Vanhaesebroeck, B; Welham M J, Kotani K, Stein R, Warne P H, Zvelebil M J, Higashi K, Volinia S, Downward J, Waterfield M D (April 1997). "P110delta, a novel phosphoinositide 3-kinase in leukocytes". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 94 (9): 4330–5. doi:10.1073/pnas.94.9.4330. ISSN 0027-8424. PMC 20722. PMID 9113989. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20722. 
3. ^ Rubio, I; Wittig U, Meyer C, Heinze R, Kadereit D, Waldmann H, Downward J, Wetzker R (November 1999). "Farnesylation of Ras is important for the interaction with phosphoinositide 3-kinase gamma". Eur. J. Biochem. (GERMANY) 266 (1): 70–82. doi:10.1046/j.1432-1327.1999.00815.x. ISSN 0014-2956. PMID 10542052. 
4. ^ Brock, Carsten; Schaefer Michael, Reusch H Peter, Czupalla Cornelia, Michalke Manuela, Spicher Karsten, Schultz Günter, Nürnberg Bernd (January 2003). "Roles of G beta gamma in membrane recruitment and activation of p110 gamma/p101 phosphoinositide 3-kinase gamma". J. Cell Biol. (United States) 160 (1): 89–99. doi:10.1083/jcb.200210115. ISSN 0021-9525. PMC 2172741. PMID 12507995. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2172741. 
5. ^ Bai, R Y; Jahn T, Schrem S, Munzert G, Weidner K M, Wang J Y, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene (ENGLAND) 17 (8): 941–8. doi:10.1038/sj.onc.1202024. ISSN 0950-9232. PMID 9747873. 
6. ^ Salgia, R; Sattler M, Pisick E, Li J L, Griffin J D (February 1996). "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". Exp. Hematol. (UNITED STATES) 24 (2): 310–3. ISSN 0301-472X. PMID 8641358. 
7. ^ Skorski, T; Kanakaraj P, Nieborowska-Skorska M, Ratajczak M Z, Wen S C, Zon G, Gewirtz A M, Perussia B, Calabretta B (July 1995). "Phosphatidylinositol-3 kinase activity is regulated by BCR/ABL and is required for the growth of Philadelphia chromosome-positive cells". Blood (UNITED STATES) 86 (2): 726–36. ISSN 0006-4971. PMID 7606002. 

Further reading

• Alloatti G, Montrucchio G, Lembo G, Hirsch E (2004). "Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease.". Biochem. Soc. Trans. 32 (Pt 2): 383–6. doi:10.1042/BST0320383. PMID 15046613. 
• Rommel C, Camps M, Ji H (2007). "PI3K delta and PI3K gamma: partners in crime in inflammation in rheumatoid arthritis and beyond?". Nat. Rev. Immunol. 7 (3): 191–201. doi:10.1038/nri2036. PMID 17290298.