SYT1

SYT1

Synaptotagmin I, also known as SYT1, is a human gene.

PBB_Summary
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summary_text = The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin I participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001). [supplied by OMIM] cite web | title = Entrez Gene: SYT1 synaptotagmin I| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6857| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mochly-Rosen D, Miller KG, Scheller RH, "et al." |title=p65 fragments, homologous to the C2 region of protein kinase C, bind to the intracellular receptors for protein kinase C. |journal=Biochemistry |volume=31 |issue= 35 |pages= 8120–4 |year= 1992 |pmid= 1326322 |doi=
*cite journal | author=Perin MS, Johnston PA, Ozcelik T, "et al." |title=Structural and functional conservation of synaptotagmin (p65) in Drosophila and humans. |journal=J. Biol. Chem. |volume=266 |issue= 1 |pages= 615–22 |year= 1991 |pmid= 1840599 |doi=
*cite journal | author=McMahon HT, Missler M, Li C, Südhof TC |title=Complexins: cytosolic proteins that regulate SNAP receptor function. |journal=Cell |volume=83 |issue= 1 |pages= 111–9 |year= 1995 |pmid= 7553862 |doi=
*cite journal | author=O'Regan S, Diebler MF, Meunier FM, Vyas S |title=A Ewing's sarcoma cell line showing some, but not all, of the traits of a cholinergic neuron. |journal=J. Neurochem. |volume=64 |issue= 1 |pages= 69–76 |year= 1995 |pmid= 7798952 |doi=
*cite journal | author=Zhang JZ, Davletov BA, Südhof TC, Anderson RG |title=Synaptotagmin I is a high affinity receptor for clathrin AP-2: implications for membrane recycling. |journal=Cell |volume=78 |issue= 5 |pages= 751–60 |year= 1994 |pmid= 8087843 |doi=
*cite journal | author=Chapman ER, Blasi J, An S, "et al." |title=Fatty acylation of synaptotagmin in PC12 cells and synaptosomes. |journal=Biochem. Biophys. Res. Commun. |volume=225 |issue= 1 |pages= 326–32 |year= 1996 |pmid= 8769138 |doi= 10.1006/bbrc.1996.1174
*cite journal | author=Perin MS |title=Mirror image motifs mediate the interaction of the COOH terminus of multiple synaptotagmins with the neurexins and calmodulin. |journal=Biochemistry |volume=35 |issue= 43 |pages= 13808–16 |year= 1996 |pmid= 8901523 |doi= 10.1021/bi960853x
*cite journal | author=Betz A, Okamoto M, Benseler F, Brose N |title=Direct interaction of the rat unc-13 homologue Munc13-1 with the N terminus of syntaxin. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2520–6 |year= 1997 |pmid= 8999968 |doi=
*cite journal | author=Shao X, Li C, Fernandez I, "et al." |title=Synaptotagmin-syntaxin interaction: the C2 domain as a Ca2+-dependent electrostatic switch. |journal=Neuron |volume=18 |issue= 1 |pages= 133–42 |year= 1997 |pmid= 9010211 |doi=
*cite journal | author=Charvin N, L'evêque C, Walker D, "et al." |title=Direct interaction of the calcium sensor protein synaptotagmin I with a cytoplasmic domain of the alpha1A subunit of the P/Q-type calcium channel. |journal=EMBO J. |volume=16 |issue= 15 |pages= 4591–6 |year= 1997 |pmid= 9303303 |doi= 10.1093/emboj/16.15.4591
*cite journal | author=Mouta Carreira C, LaVallee TM, Tarantini F, "et al." |title=S100A13 is involved in the regulation of fibroblast growth factor-1 and p40 synaptotagmin-1 release in vitro. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22224–31 |year= 1998 |pmid= 9712836 |doi=
*cite journal | author=Thomas DM, Ferguson GD, Herschman HR, Elferink LA |title=Functional and biochemical analysis of the C2 domains of synaptotagmin IV. |journal=Mol. Biol. Cell |volume=10 |issue= 7 |pages= 2285–95 |year= 1999 |pmid= 10397765 |doi=
*cite journal | author=Gerona RR, Larsen EC, Kowalchyk JA, Martin TF |title=The C terminus of SNAP25 is essential for Ca(2+)-dependent binding of synaptotagmin to SNARE complexes. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6328–36 |year= 2000 |pmid= 10692432 |doi=
*cite journal | author=Mizutani A, Fukuda M, Ibata K, "et al." |title=SYNCRIP, a cytoplasmic counterpart of heterogeneous nuclear ribonucleoprotein R, interacts with ubiquitous synaptotagmin isoforms. |journal=J. Biol. Chem. |volume=275 |issue= 13 |pages= 9823–31 |year= 2000 |pmid= 10734137 |doi=
*cite journal | author=Kimura N, Shiraishi S, Mizunashi K, "et al." |title=Synaptotagmin I expression in mast cells of normal human tissues, systemic mast cell disease, and a human mast cell leukemia cell line. |journal=J. Histochem. Cytochem. |volume=49 |issue= 3 |pages= 341–6 |year= 2001 |pmid= 11181737 |doi=
*cite journal | author=Fernández-Chacón R, Königstorfer A, Gerber SH, "et al." |title=Synaptotagmin I functions as a calcium regulator of release probability. |journal=Nature |volume=410 |issue= 6824 |pages= 41–9 |year= 2001 |pmid= 11242035 |doi= 10.1038/35065004
*cite journal | author=Fukuda M, Mikoshiba K |title=Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. |journal=Biochem. Biophys. Res. Commun. |volume=281 |issue= 5 |pages= 1226–33 |year= 2001 |pmid= 11243866 |doi= 10.1006/bbrc.2001.4512
*cite journal | author=Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS |title=Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery. |journal=J. Cell Biol. |volume=153 |issue= 5 |pages= 1111–20 |year= 2001 |pmid= 11381094 |doi=
*cite journal | author=Landriscina M, Bagalá C, Mandinova A, "et al." |title=Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 25549–57 |year= 2001 |pmid= 11432880 |doi= 10.1074/jbc.M102925200
*cite journal | author=Coppola T, Magnin-Luthi S, Perret-Menoud V, "et al." |title=Direct interaction of the Rab3 effector RIM with Ca2+ channels, SNAP-25, and synaptotagmin. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32756–62 |year= 2001 |pmid= 11438518 |doi= 10.1074/jbc.M100929200

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