NOX4

NOX4
NADPH oxidase 4
Identifiers
Symbols NOX4; KOX; KOX-1; RENOX
External IDs OMIM605261 MGI1354184 HomoloGene41065 GeneCards: NOX4 Gene
EC number 1.6.3.-
RNA expression pattern
PBB GE NOX4 219773 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 50507 50490
Ensembl ENSG00000086991 ENSMUSG00000030562
UniProt Q9NPH5 Q9JHI8
RefSeq (mRNA) NM_001143836.1 NM_015760.4
RefSeq (protein) NP_001137308.1 NP_056575.1
Location (UCSC) Chr 11:
89.06 – 89.32 Mb
Chr 7:
94.39 – 94.55 Mb
PubMed search [1] [2]

NADPH oxidase 4 is an enzyme that in humans is encoded by the NOX4 gene.

Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin (EPO; MIM 133170) in the renal cortex.[supplied by OMIM][1]

References

Further reading


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