MAP4

Microtubule-associated protein 4
Identifiers
Symbols	MAP4; DKFZp779A1753; MGC8617
External IDs	OMIM: 157132 MGI: 97178 HomoloGene: 1780 GeneCards: MAP4 Gene
Gene Ontology Molecular function • structural molecule activity • protein binding Cellular component • cytoplasm • cytoskeleton • microtubule • microtubule associated complex Biological process • negative regulation of microtubule depolymerization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4134	17758
Ensembl	ENSG00000047849	ENSMUSG00000032479
UniProt	P27816	Q05BJ2
RefSeq (mRNA)	NM_001134364.1	NM_008633
RefSeq (protein)	NP_001127836.1	NP_032659
Location (UCSC)	Chr 3: 47.89 – 48.13 Mb	Chr 9: 109.83 – 109.99 Mb
PubMed search	[1]	[2]

Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene.^[1]

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported.^[2]

References

1. ^ Chapin SJ, Bulinski JC (Jul 1991). "Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau". J Cell Sci. 98 ( Pt 1): 27–36. PMID 1905296. 
2. ^ "Entrez Gene: MAP4 microtubule-associated protein 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4134. 

Further reading

• Chapin SJ, Bulinski JC (1993). "Microtubule stabilization by assembly-promoting microtubule-associated proteins: a repeat performance.". Cell Motil. Cytoskeleton 23 (4): 236–43. doi:10.1002/cm.970230403. PMID 1477887. 
• West RR, Tenbarge KM, Olmsted JB (1991). "A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences.". J. Biol. Chem. 266 (32): 21886–96. PMID 1718985. 
• Chapin SJ, Lue CM, Yu MT, Bulinski JC (1995). "Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains.". Biochemistry 34 (7): 2289–301. doi:10.1021/bi00007a025. PMID 7857940. 
• Ookata K, Hisanaga S, Bulinski JC, et al. (1995). "Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics.". J. Cell Biol. 128 (5): 849–62. doi:10.1083/jcb.128.5.849. PMC 2120387. PMID 7876309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120387. 
• Chapin SJ, Bulinski JC (1994). "Cellular microtubules heterogeneous in their content of microtubule-associated protein 4 (MAP4).". Cell Motil. Cytoskeleton 27 (2): 133–49. doi:10.1002/cm.970270205. PMID 7909279. 
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
• Illenberger S, Drewes G, Trinczek B, et al. (1996). "Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics.". J. Biol. Chem. 271 (18): 10834–43. doi:10.1074/jbc.271.18.10834. PMID 8631898. 
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146. 
• Bulinski JC, McGraw TE, Gruber D, et al. (1998). "Overexpression of MAP4 inhibits organelle motility and trafficking in vivo.". J. Cell. Sci.. 110 ( Pt 24): 3055–64. PMID 9365275. 
• Ookata K, Hisanaga S, Sugita M, et al. (1998). "MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells: identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4.". Biochemistry 36 (50): 15873–83. doi:10.1021/bi971251w. PMID 9398320. 
• Nguyen HL, Gruber D, Bulinski JC (1999). "Microtubule-associated protein 4 (MAP4) regulates assembly, protomer-polymer partitioning and synthesis of tubulin in cultured cells.". J. Cell. Sci.. 112 ( Pt 12): 1813–24. PMID 10341201. 
• Ebneth A, Drewes G, Mandelkow EM, Mandelkow E (2000). "Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.". Cell Motil. Cytoskeleton 44 (3): 209–24. doi:10.1002/(SICI)1097-0169(199911)44:3<209::AID-CM6>3.0.CO;2-4. PMID 10542369. 
• Kitazawa H, Iida J, Uchida A, et al. (2000). "Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization.". Cell Struct. Funct. 25 (1): 33–9. doi:10.1247/csf.25.33. PMID 10791892. 
• Chang W, Gruber D, Chari S, et al. (2002). "Phosphorylation of MAP4 affects microtubule properties and cell cycle progression.". J. Cell. Sci. 114 (Pt 15): 2879–87. PMID 11683421. 
• Iida J, Itoh TJ, Hotani H, et al. (2002). "The projection domain of MAP4 suppresses the microtubule-bundling activity of the microtubule-binding domain.". J. Mol. Biol. 320 (1): 97–106. doi:10.1016/S0022-2836(02)00402-3. PMID 12079337. 
• Holmfeldt P, Brattsand G, Gullberg M (2002). "MAP4 counteracts microtubule catastrophe promotion but not tubulin-sequestering activity in intact cells.". Curr. Biol. 12 (12): 1034–9. doi:10.1016/S0960-9822(02)00897-7. PMID 12123579. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Tokuraku K, Matsushima K, Matui T, et al. (2003). "The number of repeat sequences in microtubule-associated protein 4 affects the microtubule surface properties.". J. Biol. Chem. 278 (32): 29609–18. doi:10.1074/jbc.M302186200. PMID 12773533. 
• Mangan ME, Olmsted J. (1996). "The gene for microtubule-associated protein 4 (Mtap4) maps to the distal region of mouse chromosome 9". Mamm. Genome 7 (12): 918–19. doi:10.1007/s003359900270. PMID 8995766. 

This protein-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Human proteins Protein stubs Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Discoverie of Witchcraft Athol, Nova Scotia Look at other dictionaries: Microtubule-associated protein — In cell biology, microtubule associated proteins (MAPs) are proteins that interact with the microtubules of the cellular cytoskeleton. Contents 1 Function 2 Types 2.1 Type I: MAP1 2.2 …   Wikipedia Victoria Harbour (British Columbia) — For other uses, see Victoria Harbour (disambiguation). Not to be confused with Port Victoria or Port of Victoria. Victoria Harbour Aer …   Wikipedia Phencyclidine — Systematic (IUPAC) name …   Wikipedia Toluene — IUPAC name …   Wikipedia Nitrous oxide — N2O redirects here. For other uses, see N2O (disambiguation). Laughing gas redirects here. For other uses, see Laughing gas (disambiguation). Not to be confused with nitric oxide (formula NO) or nitrogen dioxide (formula NO2). For other uses, see …   Wikipedia Domoic acid — Identifiers CAS number 14277 97 5 …   Wikipedia Glutamic acid — Glutamic acid …   Wikipedia Iaşi — Infobox Settlement official name = Iaşi image caption = The Palace of Culture image shield = Roiasi.gif‎ pushpin mapsize = 200px map caption = Location of Iaşi within Romania (in red) subdivision type = Country subdivision name = ROU subdivision… …   Wikipedia Battle of Khalkhin Gol — Infobox Military Conflict conflict=Battle of Khalkhyn Gol (Battle of Nomonhan) partof= the Soviet Japanese Border Wars campaign= caption=A Soviet BA 10 armoured car destroyed during the Battle of Khalkhin Gol date=May 11 September 16, 1939… …   Wikipedia Genpei War — Infobox Military Conflict conflict=Genpei War (Gempei War) partof=Minamoto ndash;Taira clan disputes of late Heian period caption=Scene of the Genpei war (17th century screen). date=1180 1185 place=Japan casus=Clan disputes over Imperial… …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”