MAP4

Microtubule-associated protein 4
Identifiers
Symbols	MAP4; DKFZp779A1753; MGC8617
External IDs	OMIM: 157132 MGI: 97178 HomoloGene: 1780 GeneCards: MAP4 Gene
Gene Ontology Molecular function • structural molecule activity • protein binding Cellular component • cytoplasm • cytoskeleton • microtubule • microtubule associated complex Biological process • negative regulation of microtubule depolymerization Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4134	17758
Ensembl	ENSG00000047849	ENSMUSG00000032479
UniProt	P27816	Q05BJ2
RefSeq (mRNA)	NM_001134364.1	NM_008633
RefSeq (protein)	NP_001127836.1	NP_032659
Location (UCSC)	Chr 3: 47.89 – 48.13 Mb	Chr 9: 109.83 – 109.99 Mb
PubMed search	[1]	[2]

Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene.^[1]

The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed, the full-length nature of three of which are supported.^[2]

References

1. ^ Chapin SJ, Bulinski JC (Jul 1991). "Non-neuronal 210 x 10(3) Mr microtubule-associated protein (MAP4) contains a domain homologous to the microtubule-binding domains of neuronal MAP2 and tau". J Cell Sci. 98 ( Pt 1): 27–36. PMID 1905296. 
2. ^ "Entrez Gene: MAP4 microtubule-associated protein 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4134. 

Further reading

• Chapin SJ, Bulinski JC (1993). "Microtubule stabilization by assembly-promoting microtubule-associated proteins: a repeat performance.". Cell Motil. Cytoskeleton 23 (4): 236–43. doi:10.1002/cm.970230403. PMID 1477887. 
• West RR, Tenbarge KM, Olmsted JB (1991). "A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences.". J. Biol. Chem. 266 (32): 21886–96. PMID 1718985. 
• Chapin SJ, Lue CM, Yu MT, Bulinski JC (1995). "Differential expression of alternatively spliced forms of MAP4: a repertoire of structurally different microtubule-binding domains.". Biochemistry 34 (7): 2289–301. doi:10.1021/bi00007a025. PMID 7857940. 
• Ookata K, Hisanaga S, Bulinski JC, et al. (1995). "Cyclin B interaction with microtubule-associated protein 4 (MAP4) targets p34cdc2 kinase to microtubules and is a potential regulator of M-phase microtubule dynamics.". J. Cell Biol. 128 (5): 849–62. doi:10.1083/jcb.128.5.849. PMC 2120387. PMID 7876309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2120387. 
• Chapin SJ, Bulinski JC (1994). "Cellular microtubules heterogeneous in their content of microtubule-associated protein 4 (MAP4).". Cell Motil. Cytoskeleton 27 (2): 133–49. doi:10.1002/cm.970270205. PMID 7909279. 
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474. 
• Illenberger S, Drewes G, Trinczek B, et al. (1996). "Phosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamics.". J. Biol. Chem. 271 (18): 10834–43. doi:10.1074/jbc.271.18.10834. PMID 8631898. 
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139146. 
• Bulinski JC, McGraw TE, Gruber D, et al. (1998). "Overexpression of MAP4 inhibits organelle motility and trafficking in vivo.". J. Cell. Sci.. 110 ( Pt 24): 3055–64. PMID 9365275. 
• Ookata K, Hisanaga S, Sugita M, et al. (1998). "MAP4 is the in vivo substrate for CDC2 kinase in HeLa cells: identification of an M-phase specific and a cell cycle-independent phosphorylation site in MAP4.". Biochemistry 36 (50): 15873–83. doi:10.1021/bi971251w. PMID 9398320. 
• Nguyen HL, Gruber D, Bulinski JC (1999). "Microtubule-associated protein 4 (MAP4) regulates assembly, protomer-polymer partitioning and synthesis of tubulin in cultured cells.". J. Cell. Sci.. 112 ( Pt 12): 1813–24. PMID 10341201. 
• Ebneth A, Drewes G, Mandelkow EM, Mandelkow E (2000). "Phosphorylation of MAP2c and MAP4 by MARK kinases leads to the destabilization of microtubules in cells.". Cell Motil. Cytoskeleton 44 (3): 209–24. doi:10.1002/(SICI)1097-0169(199911)44:3<209::AID-CM6>3.0.CO;2-4. PMID 10542369. 
• Kitazawa H, Iida J, Uchida A, et al. (2000). "Ser787 in the proline-rich region of human MAP4 is a critical phosphorylation site that reduces its activity to promote tubulin polymerization.". Cell Struct. Funct. 25 (1): 33–9. doi:10.1247/csf.25.33. PMID 10791892. 
• Chang W, Gruber D, Chari S, et al. (2002). "Phosphorylation of MAP4 affects microtubule properties and cell cycle progression.". J. Cell. Sci. 114 (Pt 15): 2879–87. PMID 11683421. 
• Iida J, Itoh TJ, Hotani H, et al. (2002). "The projection domain of MAP4 suppresses the microtubule-bundling activity of the microtubule-binding domain.". J. Mol. Biol. 320 (1): 97–106. doi:10.1016/S0022-2836(02)00402-3. PMID 12079337. 
• Holmfeldt P, Brattsand G, Gullberg M (2002). "MAP4 counteracts microtubule catastrophe promotion but not tubulin-sequestering activity in intact cells.". Curr. Biol. 12 (12): 1034–9. doi:10.1016/S0960-9822(02)00897-7. PMID 12123579. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Tokuraku K, Matsushima K, Matui T, et al. (2003). "The number of repeat sequences in microtubule-associated protein 4 affects the microtubule surface properties.". J. Biol. Chem. 278 (32): 29609–18. doi:10.1074/jbc.M302186200. PMID 12773533. 
• Mangan ME, Olmsted J. (1996). "The gene for microtubule-associated protein 4 (Mtap4) maps to the distal region of mouse chromosome 9". Mamm. Genome 7 (12): 918–19. doi:10.1007/s003359900270. PMID 8995766. 

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