Tryptophan dehydrogenase

In enzymology, a tryptophan dehydrogenase (EC number|1.4.1.19) is an enzyme that catalyzes the chemical reaction

:L-tryptophan + NAD(P)+ + H₂O $ightleftharpoons$ (indol-3-yl)pyruvate + NH₃ + NAD(P)H + H⁺

The 4 substrates of this enzyme are L-tryptophan, NAD⁺, NADP⁺, and H₂O, whereas its 5 products are (indol-3-yl)pyruvate, NH₃, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH2 group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-tryptophan:NAD(P)+ oxidoreductase (deaminating). Other names in common use include NAD(P)+-L-tryptophan dehydrogenase, L-tryptophan dehydrogenase, L-Trp-dehydrogenase, and TDH. This enzyme has at least one effector, calcium.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|94047-13-9."

Gene Ontology (GO) codes