BUB1B

BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast), also known as BUB1B, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer.cite web | title = Entrez Gene: BUB1B BUB1 budding uninhibited by benzimidazoles 1 homolog beta (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=701| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Posas F, Saito H |title=Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator. |journal=EMBO J. |volume=17 |issue= 5 |pages= 1385–94 |year= 1998 |pmid= 9482735 |doi= 10.1093/emboj/17.5.1385
*cite journal | author=Cahill DP, Lengauer C, Yu J, "et al." |title=Mutations of mitotic checkpoint genes in human cancers. |journal=Nature |volume=392 |issue= 6673 |pages= 300–3 |year= 1998 |pmid= 9521327 |doi= 10.1038/32688
*cite journal | author=Donadelli R, Benatti L, Remuzzi A, "et al." |title=Identification of a novel gene--SSK1--in human endothelial cells exposed to shear stress. |journal=Biochem. Biophys. Res. Commun. |volume=246 |issue= 3 |pages= 881–7 |year= 1998 |pmid= 9618306 |doi= 10.1006/bbrc.1998.8713
*cite journal | author=Taylor SS, Ha E, McKeon F |title=The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase. |journal=J. Cell Biol. |volume=142 |issue= 1 |pages= 1–11 |year= 1998 |pmid= 9660858 |doi=
*cite journal | author=Chan GK, Schaar BT, Yen TJ |title=Characterization of the kinetochore binding domain of CENP-E reveals interactions with the kinetochore proteins CENP-F and hBUBR1. |journal=J. Cell Biol. |volume=143 |issue= 1 |pages= 49–63 |year= 1998 |pmid= 9763420 |doi=
*cite journal | author=Davenport JW, Fernandes ER, Harris LD, "et al." |title=The mouse mitotic checkpoint gene bub1b, a novel bub1 family member, is expressed in a cell cycle-dependent manner. |journal=Genomics |volume=55 |issue= 1 |pages= 113–7 |year= 1999 |pmid= 9889005 |doi= 10.1006/geno.1998.5629
*cite journal | author=Jablonski SA, Chan GK, Cooke CA, "et al." |title=The hBUB1 and hBUBR1 kinases sequentially assemble onto kinetochores during prophase with hBUBR1 concentrating at the kinetochore plates in mitosis. |journal=Chromosoma |volume=107 |issue= 6-7 |pages= 386–96 |year= 1999 |pmid= 9914370 |doi=
*cite journal | author=Cahill DP, da Costa LT, Carson-Walter EB, "et al." |title=Characterization of MAD2B and other mitotic spindle checkpoint genes. |journal=Genomics |volume=58 |issue= 2 |pages= 181–7 |year= 1999 |pmid= 10366450 |doi= 10.1006/geno.1999.5831
*cite journal | author=Chan GK, Jablonski SA, Sudakin V, "et al." |title=Human BUBR1 is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. |journal=J. Cell Biol. |volume=146 |issue= 5 |pages= 941–54 |year= 1999 |pmid= 10477750 |doi=
*cite journal | author=Li W, Lan Z, Wu H, "et al." |title=BUBR1 phosphorylation is regulated during mitotic checkpoint activation. |journal=Cell Growth Differ. |volume=10 |issue= 11 |pages= 769–75 |year= 2000 |pmid= 10593653 |doi=
*cite journal | author=Futamura M, Arakawa H, Matsuda K, "et al." |title=Potential role of BRCA2 in a mitotic checkpoint after phosphorylation by hBUBR1. |journal=Cancer Res. |volume=60 |issue= 6 |pages= 1531–5 |year= 2000 |pmid= 10749118 |doi=
*cite journal | author=Wu H, Lan Z, Li W, "et al." |title=p55CDC/hCDC20 is associated with BUBR1 and may be a downstream target of the spindle checkpoint kinase. |journal=Oncogene |volume=19 |issue= 40 |pages= 4557–62 |year= 2000 |pmid= 11030144 |doi= 10.1038/sj.onc.1203803
*cite journal | author=Saffery R, Irvine DV, Griffiths B, "et al." |title=Components of the human spindle checkpoint control mechanism localize specifically to the active centromere on dicentric chromosomes. |journal=Hum. Genet. |volume=107 |issue= 4 |pages= 376–84 |year= 2001 |pmid= 11129339 |doi=
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Skoufias DA, Andreassen PR, Lacroix FB, "et al." |title=Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 8 |pages= 4492–7 |year= 2001 |pmid= 11274370 |doi= 10.1073/pnas.081076898
*cite journal | author=Kaplan KB, Burds AA, Swedlow JR, "et al." |title=A role for the Adenomatous Polyposis Coli protein in chromosome segregation. |journal=Nat. Cell Biol. |volume=3 |issue= 4 |pages= 429–32 |year= 2001 |pmid= 11283619 |doi= 10.1038/35070123
*cite journal | author=Sudakin V, Chan GK, Yen TJ |title=Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2. |journal=J. Cell Biol. |volume=154 |issue= 5 |pages= 925–36 |year= 2001 |pmid= 11535616 |doi= 10.1083/jcb.200102093
*cite journal | author=Tang Z, Bharadwaj R, Li B, Yu H |title=Mad2-Independent inhibition of APCCdc20 by the mitotic checkpoint protein BubR1. |journal=Dev. Cell |volume=1 |issue= 2 |pages= 227–37 |year= 2001 |pmid= 11702782 |doi=
*cite journal | author=Shichiri M, Yoshinaga K, Hisatomi H, "et al." |title=Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. |journal=Cancer Res. |volume=62 |issue= 1 |pages= 13–7 |year= 2002 |pmid= 11782350 |doi=
*cite journal | author=Taylor SS, Hussein D, Wang Y, "et al." |title=Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. |journal=J. Cell. Sci. |volume=114 |issue= Pt 24 |pages= 4385–95 |year= 2002 |pmid= 11792804 |doi=

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