Polyamine oxidase

Polyamine oxidase

In enzymology, a polyamine oxidase (EC number|1.5.3.11) is an enzyme that catalyzes the chemical reaction

:N1-acetylspermine + O2 + H2O ightleftharpoons N1-acetylspermidine + 3-aminopropanal + H2O2

The 3 substrates of this enzyme are N1-acetylspermine, O2, and H2O, whereas its 3 products are N1-acetylspermidine, 3-aminopropanal, and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N1-acetylspermidine:oxygen oxidoreductase (deaminating). This enzyme is also called 1-N-acetylspermidine:oxygen oxidoreductase (deaminating). It has 2 cofactors: FAD, and Iron.

tructural studies

As of late 2007, 9 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1B37, PDB link|1H81, PDB link|1H82, PDB link|1H83, PDB link|1H84, PDB link|1H86, PDB link|1RSG, PDB link|1YY5, and PDB link|1Z6L.

References

*
*

External links

::"The CAS registry number for this enzyme class is CAS registry|294646-71-2."

Gene Ontology (GO) codes


Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • polyamine oxidase — noun Any enzyme that catalyzes the oxidation of a polyamine, but especially of acetylspermine to acetylspermidine and aminopropanal …   Wiktionary

  • polyamine — Class name for substances of the general formula H2N(CH2)nNH2, H2N(CH2)nNH(CH2)nNH2, H2N(CH2)nNH(CH2)nNH(CH2)nNH2, where n = 3, 4, or 5. Many polyamines arise by bacterial …   Medical dictionary

  • PAOX — Polyamine oxidase (exo N4 amino) Identifiers Symbols PAOX; DKFZp434J245; MGC45464; PAO External IDs …   Wikipedia

  • SMOX — Spermine oxidase, also known as SMOX, is a human gene.cite web | title = Entrez Gene: SMOX spermine oxidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=54498| accessdate = ] PBB Summary section title =… …   Wikipedia

  • Flavin containing amine oxidoreductase — Pfam box Symbol = Amino oxidase Name = Flavin containing amine oxidoreductase width = caption = Pfam= PF01593 InterPro= IPR002937 SMART= PROSITE = PDOC00755 SCOP = 1b37 TCDB = OPM family= 128 OPM protein= 1sez PDB=PDB3|1tdoA:61 499 PDB3|1tdkA:61… …   Wikipedia

  • List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia

  • SAT1 (gene) — Spermidine/spermine N1 acetyltransferase 1, also known as SAT1, is a human gene.cite web | title = Entrez Gene: SAT1 spermidine/spermine N1 acetyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… …   Wikipedia

  • Penicillium chrysogenum — Taxobox name = Penicillium chrysogenum image width = 240px image caption = Penicillium chrysogenum regnum = Fungi divisio = Ascomycota subdivisio = Pezizomycotina classis = Eurotiomycetes ordo = Eurotiales familia = Trichocomaceae genus =… …   Wikipedia

  • ceruloplasmin — A blue, copper containing α globulin of blood plasma, with a molecular weight of about 122,000 and 6 or 7 atoms of copper per molecule; involved in copper transport and regulation, and can reduce O2 directly without known intermediates; has… …   Medical dictionary

  • PAO — peak acid output; periacetabular osteotomy; peripheral airway obstruction; plasma amine oxidase; polyamine oxidase; pulmonary artery occlusion; pustulotic arthroosteitis * * * peak acid output …   Medical dictionary

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”