SAT1 (gene)

Spermidine/spermine N1-acetyltransferase 1, also known as SAT1, is a human gene.cite web | title = Entrez Gene: SAT1 spermidine/spermine N1-acetyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6303| accessdate = ]

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summary_text = Spermidine/spermine N(1)-acetyltransferase (SPD/SPM acetyltransferase) is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the N(1)-acetylation of spermidine and spermine and, by the successive activity of polyamine oxidase, spermine can be converted to spermidine and spermidine to putrescine. [supplied by OMIM] cite web | title = Entrez Gene: SAT1 spermidine/spermine N1-acetyltransferase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6303| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Lake JA, Carr J, Feng F, "et al." |title=The role of Vif during HIV-1 infection: interaction with novel host cellular factors. |journal=J. Clin. Virol. |volume=26 |issue= 2 |pages= 143–52 |year= 2003 |pmid= 12600646 |doi=
*cite journal | author=Xiao L, Celano P, Mank AR, "et al." |title=Structure of the human spermidine/spermine N1-acetyltransferase gene (exon/intron gene organization and localization to Xp22.1). |journal=Biochem. Biophys. Res. Commun. |volume=187 |issue= 3 |pages= 1493–502 |year= 1992 |pmid= 1417826 |doi=
*cite journal | author=Xiao L, Celano P, Mank AR, "et al." |title=Characterization of a full-length cDNA which codes for the human spermidine/spermine N1-acetyltransferase. |journal=Biochem. Biophys. Res. Commun. |volume=179 |issue= 1 |pages= 407–15 |year= 1991 |pmid= 1652956 |doi=
*cite journal | author=Casero RA, Celano P, Ervin SJ, "et al." |title=Isolation and characterization of a cDNA clone that codes for human spermidine/spermine N1-acetyltransferase. |journal=J. Biol. Chem. |volume=266 |issue= 2 |pages= 810–4 |year= 1991 |pmid= 1985966 |doi=
*cite journal | author=Libby PR, Ganis B, Bergeron RJ, Porter CW |title=Characterization of human spermidine/spermine N1-acetyltransferase purified from cultured melanoma cells. |journal=Arch. Biochem. Biophys. |volume=284 |issue= 2 |pages= 238–44 |year= 1991 |pmid= 1989509 |doi=
*cite journal | author=Casero RA, Celano P, Ervin SJ, "et al." |title=High specific induction of spermidine/spermine N1-acetyltransferase in a human large cell lung carcinoma. |journal=Biochem. J. |volume=270 |issue= 3 |pages= 615–20 |year= 1990 |pmid= 2241897 |doi=
*cite journal | author=Casero RA, Gabrielson EW, Pegg AE |title=Immunohistochemical staining of human spermidine/spermine N1-acetyltransferase superinduced in response to treatment with antitumor polyamine analogues. |journal=Cancer Res. |volume=54 |issue= 15 |pages= 3955–8 |year= 1994 |pmid= 8033120 |doi=
*cite journal | author=Xiao L, Casero RA |title=Differential transcription of the human spermidine/spermine N1-acetyltransferase (SSAT) gene in human lung carcinoma cells. |journal=Biochem. J. |volume=313 ( Pt 2) |issue= |pages= 691–6 |year= 1996 |pmid= 8573111 |doi=
*cite journal | author=Coleman CS, Huang H, Pegg AE |title=Structure and critical residues at the active site of spermidine/spermine-N1-acetyltransferase. |journal=Biochem. J. |volume=316 ( Pt 3) |issue= |pages= 697–701 |year= 1996 |pmid= 8670140 |doi=
*cite journal | author=Bordin L, Vargiu C, Colombatto S, "et al." |title=Casein kinase 2 phosphorylates recombinant human spermidine/spermine N1-acetyltransferase on both serine and threonine residues. |journal=Biochem. Biophys. Res. Commun. |volume=229 |issue= 3 |pages= 845–51 |year= 1997 |pmid= 8954982 |doi= 10.1006/bbrc.1996.1890
*cite journal | author=Bettuzzi S, Davalli P, Astancolle S, "et al." |title=Tumor progression is accompanied by significant changes in the levels of expression of polyamine metabolism regulatory genes and clusterin (sulfated glycoprotein 2) in human prostate cancer specimens. |journal=Cancer Res. |volume=60 |issue= 1 |pages= 28–34 |year= 2000 |pmid= 10646846 |doi=
*cite journal | author=Simpson JC, Wellenreuther R, Poustka A, "et al." |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287–92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058
*cite journal | author=Coleman CS, Pegg AE |title=Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation. |journal=Biochem. J. |volume=358 |issue= Pt 1 |pages= 137–45 |year= 2001 |pmid= 11485561 |doi=
*cite journal | author=Bordin L, Vargiu C, Clari G, "et al." |title=Phosphorylation of recombinant human spermidine/spermine N(1)-acetyltransferase by CK1 and modulation of its binding to mitochondria: a comparison with CK2. |journal=Biochem. Biophys. Res. Commun. |volume=290 |issue= 1 |pages= 463–8 |year= 2002 |pmid= 11779193 |doi= 10.1006/bbrc.2001.6204
*cite journal | author=Nikiforova NN, Velikodvorskaja TV, Kachko AV, "et al." |title=Induction of alternatively spliced spermidine/spermine N1-acetyltransferase mRNA in the human kidney cells infected by venezuelan equine encephalitis and tick-borne encephalitis viruses. |journal=Virology |volume=297 |issue= 2 |pages= 163–71 |year= 2002 |pmid= 12083816 |doi=
*cite journal | author=Gimelli G, Giglio S, Zuffardi O, "et al." |title=Gene dosage of the spermidine/spermine N(1)-acetyltransferase ( SSAT) gene with putrescine accumulation in a patient with a Xp21.1p22.12 duplication and keratosis follicularis spinulosa decalvans (KFSD). |journal=Hum. Genet. |volume=111 |issue= 3 |pages= 235–41 |year= 2002 |pmid= 12215835 |doi= 10.1007/s00439-002-0791-6
*cite journal | author=Tomitori H, Nenoi M, Mita K, "et al." |title=Functional characterization of the human spermidine/spermine N(1)-acetyltransferase gene promoter. |journal=Biochim. Biophys. Acta |volume=1579 |issue= 2-3 |pages= 180–4 |year= 2003 |pmid= 12427553 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Izmailova E, Bertley FM, Huang Q, "et al." |title=HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. |journal=Nat. Med. |volume=9 |issue= 2 |pages= 191–7 |year= 2003 |pmid= 12539042 |doi= 10.1038/nm822

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