SMOX

Spermine oxidase, also known as SMOX, is a human gene.cite web | title = Entrez Gene: SMOX spermine oxidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54498| accessdate = ]

PBB_Summary
section_title =
summary_text = The product of this gene is the polyamine oxidase. This enzyme potentially represents a new class of catabolic enzymes in the mammalian polyamine metabolic pathway capable of the efficient oxidation of polyamines. More than five transcript variants encoding four active isoenzymes have been identified for this gene, however, not all variants have been fully described. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.cite web | title = Entrez Gene: SMOX spermine oxidase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54498| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Seiler N |title=Catabolism of polyamines. |journal=Amino Acids |volume=26 |issue= 3 |pages= 217–33 |year= 2005 |pmid= 15221502 |doi= 10.1007/s00726-004-0070-z
*cite journal | author=Hölttä E |title=Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidase. |journal=Biochemistry |volume=16 |issue= 1 |pages= 91–100 |year= 1977 |pmid= 12798 |doi=
*cite journal | author=Tsukada T, Furusako S, Maekawa S, "et al." |title=Purification by affinity chromatography and characterization of porcine liver cytoplasmic polyamine oxidase. |journal=Int. J. Biochem. |volume=20 |issue= 7 |pages= 695–702 |year= 1988 |pmid= 3181599 |doi=
*cite journal | author=Wang Y, Devereux W, Woster PM, "et al." |title=Cloning and characterization of a human polyamine oxidase that is inducible by polyamine analogue exposure. |journal=Cancer Res. |volume=61 |issue= 14 |pages= 5370–3 |year= 2001 |pmid= 11454677 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Vujcic S, Diegelman P, Bacchi CJ, "et al." |title=Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. |journal=Biochem. J. |volume=367 |issue= Pt 3 |pages= 665–75 |year= 2002 |pmid= 12141946 |doi= 10.1042/BJ20020720
*cite journal | author=Murray-Stewart T, Wang Y, Devereux W, Casero RA |title=Cloning and characterization of multiple human polyamine oxidase splice variants that code for isoenzymes with different biochemical characteristics. |journal=Biochem. J. |volume=368 |issue= Pt 3 |pages= 673–7 |year= 2003 |pmid= 12398765 |doi= 10.1042/BJ20021587
*cite journal | author=Cervelli M, Polticelli F, Federico R, Mariottini P |title=Heterologous expression and characterization of mouse spermine oxidase. |journal=J. Biol. Chem. |volume=278 |issue= 7 |pages= 5271–6 |year= 2003 |pmid= 12458219 |doi= 10.1074/jbc.M207888200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Wang Y, Murray-Stewart T, Devereux W, "et al." |title=Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. |journal=Biochem. Biophys. Res. Commun. |volume=304 |issue= 4 |pages= 605–11 |year= 2003 |pmid= 12727196 |doi=
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Cervelli M, Bellini A, Bianchi M, "et al." |title=Mouse spermine oxidase gene splice variants. Nuclear subcellular localization of a novel active isoform. |journal=Eur. J. Biochem. |volume=271 |issue= 4 |pages= 760–70 |year= 2004 |pmid= 14764092 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Pledgie A, Huang Y, Hacker A, "et al." |title=Spermine oxidase SMO(PAOh1), Not N1-acetylpolyamine oxidase PAO, is the primary source of cytotoxic H2O2 in polyamine analogue-treated human breast cancer cell lines. |journal=J. Biol. Chem. |volume=280 |issue= 48 |pages= 39843–51 |year= 2006 |pmid= 16207710 |doi= 10.1074/jbc.M508177200

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