Nitrite reductase (NAD(P)H)

nitrite reductase [NAD(P)H]
Identifiers
EC number	1.7.1.4
CAS number	9029-29-2
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a nitrite reductase [NAD(P)H] (EC 1.7.1.4) is an enzyme that catalyzes the chemical reaction

ammonium hydroxide + 3 NAD(P)+ + H₂O $\rightleftharpoons$ nitrite + 3 NAD(P)H + 3 H⁺

The 4 substrates of this enzyme are ammonium hydroxide, NAD⁺, NADP⁺, and H₂O, whereas its 4 products are nitrite, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is ammonium-hydroxide:NAD(P)+ oxidoreductase. Other names in common use include nitrite reductase (reduced nicotinamide adenine dinucleotide, (phosphate)), NADH-nitrite oxidoreductase, NADPH-nitrite reductase, assimilatory nitrite reductase, nitrite reductase [NAD(P)H2], and NAD(P)H2:nitrite oxidoreductase. This enzyme participates in nitrogen metabolism. It has 3 cofactors: FAD, Iron, and Siroheme.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 2JO6.

References

• Cammack R, Jackson RH, Cornish-Bowden A, Cole JA (1982). "Electron-spin-resonance studies of the NADH-dependent nitrite reductase from Escherichia coli K12". Biochem. J. 207 (2): 333–9. PMC 1153865. PMID 6297458. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1153865. 
• Lazzarini RA and Atkinson DE (1961). "A triphosphopyridine nucleotide-specific nitrite reductase from Escherichia coli". J. Biol. Chem. 236: 3330–3335. PMID 14463130. 
• Nicholas DJD, Medina A and Jones OTG (1960). "A nitrite reductase from Neurospora crassa". Biochim. Biophys. Acta 37 (3): 468. doi:10.1016/0006-3002(60)90503-5. PMID 14426899. 
• Taniguchi H, Mitsui H, Nakamura K and Egami F. Ann. Acad. Sci. Fenn. Ser. A II 60 (1955) 200. 
• Colandene JD, Garrett RH (1996). "Functional dissection and site-directed mutagenesis of the structural gene for NAD(P)H-nitrite reductase in Neurospora crassa". J. Biol. Chem. 271 (39): 24096–104. doi:10.1074/jbc.271.39.24096. PMID 8798648. 

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