N6-methyl-lysine oxidase

N6-methyl-lysine oxidase
N6-methyl-lysine oxidase
Identifiers
EC number 1.5.3.4
CAS number 37256-28-3
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N6-methyl-lysine oxidase (EC 1.5.3.4) is an enzyme that catalyzes the chemical reaction

N6-methyl-L-lysine + H2O + O2 \rightleftharpoons L-lysine + formaldehyde + H2O2

The 3 substrates of this enzyme are N6-methyl-L-lysine, H2O, and O2, whereas its 3 products are L-lysine, formaldehyde, and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N6-methyl-L-lysine:oxygen oxidoreductase (demethylating). Other names in common use include epsilon-alkyl-L-lysine:oxygen oxidoreductase, N6-methyllysine oxidase, epsilon-N-methyllysine demethylase, epsilon-alkyllysinase, and 6-N-methyl-L-lysine:oxygen oxidoreductase (demethylating).

References

  • Kim S, Benoiton L and Paik WK (1964). "alpha-Alkyllysinase. Purification and properties of the enzyme". J. Biol. Chem. 239: 3790–3796.