CFLAR

CFLAR
CASP8 and FADD-like apoptosis regulator

Rendering based on PDB 3H11.
Identifiers
Symbols CFLAR; CASH; CASP8AP1; CLARP; Casper; FLAME; FLAME-1; FLAME1; FLIP; I-FLICE; MRIT; c-FLIP; c-FLIPL; c-FLIPR; c-FLIPS
External IDs OMIM603599 MGI1336166 HomoloGene7652 GeneCards: CFLAR Gene
RNA expression pattern
PBB GE CFLAR 211317 s at tn.png
PBB GE CFLAR 208485 x at tn.png
PBB GE CFLAR 209508 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8837 12633
Ensembl ENSG00000003402 ENSMUSG00000026031
UniProt O15519 Q812G4
RefSeq (mRNA) NM_001127183.2 NM_009805
RefSeq (protein) NP_001120655.1 NP_033935
Location (UCSC) Chr 2:
201.98 – 202.03 Mb
Chr 1:
58.77 – 58.82 Mb
PubMed search [1] [2]

CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene.[1][2] Also called FLICE-like inhibitory protein (FLIP).


References

  1. ^ Shu HB, Halpin DR, Goeddel DV (Jul 1997). "Casper is a FADD- and caspase-related inducer of apoptosis". Immunity 6 (6): 751–63. doi:10.1016/S1074-7613(00)80450-1. PMID 9208847. 
  2. ^ Irmler M, Thome M, Hahne M, Schneider P, Hofmann K, Steiner V, Bodmer JL, Schroter M, Burns K, Mattmann C, Rimoldi D, French LE, Tschopp J (Jul 1997). "Inhibition of death receptor signals by cellular FLIP". Nature 388 (6638): 190–5. doi:10.1038/40657. PMID 9217161. 

Further reading

  • Abe K, Kurakin A, Mohseni-Maybodi M, et al. (2001). "The complexity of TNF-related apoptosis-inducing ligand.". Ann. N. Y. Acad. Sci. 926 (1): 52–63. doi:10.1111/j.1749-6632.2000.tb05598.x. PMID 11193041. 
  • Dutton A, Young LS, Murray PG (2006). "The role of cellular FLICE inhibitory protein (c-FLIP) in the pathogenesis and treatment of cancer.". Expert Opin. Ther. Targets 10 (1): 27–35. doi:10.1517/14728222.10.1.27. PMID 16441226. 




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