TRAF5

TNF receptor-associated factor 5, also known as TRAF5, is a human gene.

PBB_Summary
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summary_text = The scaffold protein encoded by this gene is a member of the tumor necrosis factor receptor-associated factor (TRAF) protein family and contains a meprin and TRAF homology (MATH) domain, a RING-type zinc finger, and two TRAF-type zinc fingers. TRAF proteins are associated with, and mediate signal transduction from members of the TNF receptor superfamily. This protein is one of the components of a multiple protein complex which binds to tumor necrosis factor (TNF) receptor cytoplasmic domains and mediates TNF-induced activation. Alternate transcriptional splice variants have been characterized.cite web | title = Entrez Gene: TRAF5 TNF receptor-associated factor 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7188| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wajant H, Henkler F, Scheurich P |title=The TNF-receptor-associated factor family: scaffold molecules for cytokine receptors, kinases and their regulators. |journal=Cell. Signal. |volume=13 |issue= 6 |pages= 389–400 |year= 2001 |pmid= 11384837 |doi=
*cite journal | author=Bradley JR, Pober JS |title=Tumor necrosis factor receptor-associated factors (TRAFs). |journal=Oncogene |volume=20 |issue= 44 |pages= 6482–91 |year= 2001 |pmid= 11607847 |doi= 10.1038/sj.onc.1204788
*cite journal | author=Nakano H, Oshima H, Chung W, "et al." |title=TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 14661–4 |year= 1996 |pmid= 8663299 |doi=
*cite journal | author=Ishida TK, Tojo T, Aoki T, "et al." |title=TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 18 |pages= 9437–42 |year= 1996 |pmid= 8790348 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Ansieau S, Scheffrahn I, Mosialos G, "et al." |title=Tumor necrosis factor receptor-associated factor (TRAF)-1, TRAF-2, and TRAF-3 interact in vivo with the CD30 cytoplasmic domain; TRAF-2 mediates CD30-induced nuclear factor kappa B activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 14053–8 |year= 1997 |pmid= 8943059 |doi=
*cite journal | author=Aizawa S, Nakano H, Ishida T, "et al." |title=Tumor necrosis factor receptor-associated factor (TRAF) 5 and TRAF2 are involved in CD30-mediated NFkappaB activation. |journal=J. Biol. Chem. |volume=272 |issue= 4 |pages= 2042–5 |year= 1997 |pmid= 8999898 |doi=
*cite journal | author=Tang XX, Pleasure DE, Ikegaki N |title=cDNA cloning, chromosomal localization, and expression pattern of EPLG8, a new member of the EPLG gene family encoding ligands of EPH-related protein-tyrosine kinase receptors. |journal=Genomics |volume=41 |issue= 1 |pages= 17–24 |year= 1997 |pmid= 9126477 |doi= 10.1006/geno.1997.4615
*cite journal | author=Hsu H, Solovyev I, Colombero A, "et al." |title=ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. |journal=J. Biol. Chem. |volume=272 |issue= 21 |pages= 13471–4 |year= 1997 |pmid= 9153189 |doi=
*cite journal | author=Marsters SA, Ayres TM, Skubatch M, "et al." |title=Herpesvirus entry mediator, a member of the tumor necrosis factor receptor (TNFR) family, interacts with members of the TNFR-associated factor family and activates the transcription factors NF-kappaB and AP-1. |journal=J. Biol. Chem. |volume=272 |issue= 22 |pages= 14029–32 |year= 1997 |pmid= 9162022 |doi=
*cite journal | author=Nakano H, Shindo M, Yamada K, "et al." |title=Human TNF receptor-associated factor 5 (TRAF5): cDNA cloning, expression and assignment of the TRAF5 gene to chromosome 1q32. |journal=Genomics |volume=42 |issue= 1 |pages= 26–32 |year= 1997 |pmid= 9177772 |doi=
*cite journal | author=Song HY, Régnier CH, Kirschning CJ, "et al." |title=Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9792–6 |year= 1997 |pmid= 9275204 |doi=
*cite journal | author=Kawamata S, Hori T, Imura A, "et al." |title=Activation of OX40 signal transduction pathways leads to tumor necrosis factor receptor-associated factor (TRAF) 2- and TRAF5-mediated NF-kappaB activation. |journal=J. Biol. Chem. |volume=273 |issue= 10 |pages= 5808–14 |year= 1998 |pmid= 9488716 |doi=
*cite journal | author=Mizushima S, Fujita M, Ishida T, "et al." |title=Cloning and characterization of a cDNA encoding the human homolog of tumor necrosis factor receptor-associated factor 5 (TRAF5). |journal=Gene |volume=207 |issue= 2 |pages= 135–40 |year= 1998 |pmid= 9511754 |doi=
*cite journal | author=Akiba H, Nakano H, Nishinaka S, "et al." |title=CD27, a member of the tumor necrosis factor receptor superfamily, activates NF-kappaB and stress-activated protein kinase/c-Jun N-terminal kinase via TRAF2, TRAF5, and NF-kappaB-inducing kinase. |journal=J. Biol. Chem. |volume=273 |issue= 21 |pages= 13353–8 |year= 1998 |pmid= 9582383 |doi=
*cite journal | author=McCarthy JV, Ni J, Dixit VM |title=RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase. |journal=J. Biol. Chem. |volume=273 |issue= 27 |pages= 16968–75 |year= 1998 |pmid= 9642260 |doi=
*cite journal | author=Pullen SS, Miller HG, Everdeen DS, "et al." |title=CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. |journal=Biochemistry |volume=37 |issue= 34 |pages= 11836–45 |year= 1998 |pmid= 9718306 |doi= 10.1021/bi981067q
*cite journal | author=Wong BR, Josien R, Lee SY, "et al." |title=The TRAF family of signal transducers mediates NF-kappaB activation by the TRANCE receptor. |journal=J. Biol. Chem. |volume=273 |issue= 43 |pages= 28355–9 |year= 1998 |pmid= 9774460 |doi=
*cite journal | author=Nishitoh H, Saitoh M, Mochida Y, "et al." |title=ASK1 is essential for JNK/SAPK activation by TRAF2. |journal=Mol. Cell |volume=2 |issue= 3 |pages= 389–95 |year= 1998 |pmid= 9774977 |doi=
*cite journal | author=Tsukamoto N, Kobayashi N, Azuma S, "et al." |title=Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 4 |pages= 1234–9 |year= 1999 |pmid= 9990007 |doi=

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