Dimethylglycine dehydrogenase

dimethylglycine dehydrogenase
Identifiers
EC number	1.5.99.2
CAS number	37256-30-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a dimethylglycine dehydrogenase (EC 1.5.99.2) is an enzyme that catalyzes the chemical reaction

N,N-dimethylglycine + acceptor + H₂O $\rightleftharpoons$ sarcosine + formaldehyde + reduced acceptor

The 3 substrates of this enzyme are N,N-dimethylglycine, acceptor, and H₂O, whereas its 3 products are sarcosine, formaldehyde, and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with other acceptors. The systematic name of this enzyme class is N,N-dimethylglycine:acceptor oxidoreductase (demethylating). Other names in common use include N,N-dimethylglycine oxidase, and N,N-dimethylglycine:(acceptor) oxidoreductase (demethylating). This enzyme participates in glycine, serine and threonine metabolism. It employs one cofactor, FAD.

References

• FRISELL WR, MACKENZIE CG (1962). "Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase". J. Biol. Chem. 237: 94–8. PMID 13895406. 
• HOSKINS DD, MACKENZIE CG (1961). "Solubilization and electron transfer flavoprtein requirement of mitochondrial sarcosine dehydrogenase and dimethylglycine dehydrogenase". J. Biol. Chem. 236: 177–83. PMID 13716069. 

This EC 1.5 enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Oxidoreductase stubs EC 1.5.99 Flavin enzymes Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Нужна курсовая? Dimethylamine dehydrogenase Cowley High School Look at other dictionaries: dimethylglycine dehydrogenase — di·meth·yl·gly·cine de·hy·dro·gen·ase (di meth″əl gliґsēn de hiґdro jən ās) [EC 1.5.99.2] a mitochondrial flavoprotein enzyme of the oxidoreductase class that catalyzes the oxidative demethylation of N,N dimethylglycine… …   Medical dictionary List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia SARDH — Sarcosine dehydrogenase, also known as SARDH, is a human gene.cite web | title = Entrez Gene: SARDH sarcosine dehydrogenase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=1757| accessdate = ] PBB Summary… …   Wikipedia electron transfer flavoprotein — (ETF) a component of a side chain of redox reactions by which electrons are funneled to ubiquinone and thus the electron transport chain; electrons from acyl CoA thioesters and choline are transferred via the flavin of acyl CoA dehydrogenases,… …   Medical dictionary Trimethylglycine — Trimethylglycine …   Wikipedia Sarcosine — IUPAC name 2 (Methylamino)acetic acid …   Wikipedia Gamma-Hydroxybutyric acid — γ Hydroxybutyric acid Systematic (IUPAC) name 4 Hydroxybutanoic acid …   Wikipedia D-amino acid oxidase — Identifiers EC number 1.4.3.3 CAS number 9000 88 8 …   Wikipedia List of EC numbers (EC 2) — This list contains a list of EC numbers for the second group, EC 2, transferases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 2.1: Transferring One… …   Wikipedia Glycine — For the plant, see Glycine (plant). Glycine[1] …   Wikipedia 18+ © Academic, 2000-2024 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link … Do a right-click on the link above and select “Copy Link”