EPS15

Epidermal growth factor receptor pathway substrate 15, also known as EPS15, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.cite web | title = Entrez Gene: EPS15 epidermal growth factor receptor pathway substrate 15| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2060| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Schumacher C, Knudsen BS, Ohuchi T, "et al." |title=The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R. |journal=J. Biol. Chem. |volume=270 |issue= 25 |pages= 15341–7 |year= 1995 |pmid= 7797522 |doi=
*cite journal | author=Bernard OA, Mauchauffe M, Mecucci C, "et al." |title=A novel gene, AF-1p, fused to HRX in t(1;11)(p32;q23), is not related to AF-4, AF-9 nor ENL. |journal=Oncogene |volume=9 |issue= 4 |pages= 1039–45 |year= 1994 |pmid= 8134107 |doi=
*cite journal | author=Wong WT, Kraus MH, Carlomagno F, "et al." |title=The human eps15 gene, encoding a tyrosine kinase substrate, is conserved in evolution and maps to 1p31-p32. |journal=Oncogene |volume=9 |issue= 6 |pages= 1591–7 |year= 1994 |pmid= 8183552 |doi=
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Benmerah A, Bégue B, Dautry-Varsat A, Cerf-Bensussan N |title=The ear of alpha-adaptin interacts with the COOH-terminal domain of the Eps 15 protein. |journal=J. Biol. Chem. |volume=271 |issue= 20 |pages= 12111–6 |year= 1996 |pmid= 8662627 |doi=
*cite journal | author=Matsuda M, Ota S, Tanimura R, "et al." |title=Interaction between the amino-terminal SH3 domain of CRK and its natural target proteins. |journal=J. Biol. Chem. |volume=271 |issue= 24 |pages= 14468–72 |year= 1996 |pmid= 8662907 |doi=
*cite journal | author=van Delft S, Schumacher C, Hage W, "et al." |title=Association and colocalization of Eps15 with adaptor protein-2 and clathrin. |journal=J. Cell Biol. |volume=136 |issue= 4 |pages= 811–21 |year= 1997 |pmid= 9049247 |doi=
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Tebar F, Confalonieri S, Carter RE, "et al." |title=Eps15 is constitutively oligomerized due to homophilic interaction of its coiled-coil region. |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15413–8 |year= 1997 |pmid= 9182572 |doi=
*cite journal | author=Salcini AE, Confalonieri S, Doria M, "et al." |title=Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. |journal=Genes Dev. |volume=11 |issue= 17 |pages= 2239–49 |year= 1997 |pmid= 9303539 |doi=
*cite journal | author=Cupers P, ter Haar E, Boll W, Kirchhausen T |title=Parallel dimers and anti-parallel tetramers formed by epidermal growth factor receptor pathway substrate clone 15. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 33430–4 |year= 1998 |pmid= 9407139 |doi=
*cite journal | author=Haffner C, Takei K, Chen H, "et al." |title=Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15. |journal=FEBS Lett. |volume=419 |issue= 2-3 |pages= 175–80 |year= 1998 |pmid= 9428629 |doi=
*cite journal | author=Benmerah A, Lamaze C, Bègue B, "et al." |title=AP-2/Eps15 interaction is required for receptor-mediated endocytosis. |journal=J. Cell Biol. |volume=140 |issue= 5 |pages= 1055–62 |year= 1998 |pmid= 9490719 |doi=
*cite journal | author=de Beer T, Carter RE, Lobel-Rice KE, "et al." |title=Structure and Asn-Pro-Phe binding pocket of the Eps15 homology domain. |journal=Science |volume=281 |issue= 5381 |pages= 1357–60 |year= 1998 |pmid= 9721102 |doi=
*cite journal | author=Chen H, Fre S, Slepnev VI, "et al." |title=Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. |journal=Nature |volume=394 |issue= 6695 |pages= 793–7 |year= 1998 |pmid= 9723620 |doi= 10.1038/29555
*cite journal | author=Lewin DA, Sheff D, Ooi CE, "et al." |title=Cloning, expression, and localization of a novel gamma-adaptin-like molecule. |journal=FEBS Lett. |volume=435 |issue= 2-3 |pages= 263–8 |year= 1998 |pmid= 9762922 |doi=
*cite journal | author=Sengar AS, Wang W, Bishay J, "et al." |title=The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15. |journal=EMBO J. |volume=18 |issue= 5 |pages= 1159–71 |year= 1999 |pmid= 10064583 |doi= 10.1093/emboj/18.5.1159
*cite journal | author=Poupon V, Bègue B, Gagnon J, "et al." |title=Molecular cloning and characterization of MT-ACT48, a novel mitochondrial acyl-CoA thioesterase. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19188–94 |year= 1999 |pmid= 10383425 |doi=
*cite journal | author=Nakashima S, Morinaka K, Koyama S, "et al." |title=Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. |journal=EMBO J. |volume=18 |issue= 13 |pages= 3629–42 |year= 1999 |pmid= 10393179 |doi= 10.1093/emboj/18.13.3629
*cite journal | author=Stephens DJ, Banting G |title=Direct interaction of the trans-Golgi network membrane protein, TGN38, with the F-actin binding protein, neurabin. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30080–6 |year= 1999 |pmid= 10514494 |doi=

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