ITSN1

Intersectin 1 (SH3 domain protein), also known as ITSN1, is a human gene.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cytoplasmic membrane-associated protein that indirectly coordinates endocytic membrane traffic with the actin assembly machinery. In addition, the encoded protein may regulate the formation of clathrin-coated vesicles and could be involved in synaptic vesicle recycling. This protein has been shown to interact with dynamin, CDC42, SNAP23, SNAP25, SPIN90, EPS15, EPN1, EPN2, and STN2. Multiple transcript variants encoding different isoforms have been found for this gene, but the full-length nature of only two of them have been characterized so far.cite web | title = Entrez Gene: ITSN1 intersectin 1 (SH3 domain protein)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6453| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Keating DJ, Chen C, Pritchard MA |title=Alzheimer's disease and endocytic dysfunction: clues from the Down syndrome-related proteins, DSCR1 and ITSN1. |journal=Ageing Res. Rev. |volume=5 |issue= 4 |pages= 388–401 |year= 2006 |pmid= 16442855 |doi= 10.1016/j.arr.2005.11.001
*cite journal | author=Chen H, Antonarakis SE |title=The SH3D1A gene maps to human chromosome 21q22.1-->q22.2. |journal=Cytogenet. Cell Genet. |volume=78 |issue= 3-4 |pages= 213–5 |year= 1998 |pmid= 9465890 |doi=
*cite journal | author=Sparks AB, Hoffman NG, McConnell SJ, "et al." |title=Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins. |journal=Nat. Biotechnol. |volume=14 |issue= 6 |pages= 741–4 |year= 1998 |pmid= 9630982 |doi= 10.1038/nbt0696-741
*cite journal | author=Guipponi M, Scott HS, Chen H, "et al." |title=Two isoforms of a human intersectin (ITSN) protein are produced by brain-specific alternative splicing in a stop codon. |journal=Genomics |volume=53 |issue= 3 |pages= 369–76 |year= 1998 |pmid= 9799604 |doi= 10.1006/geno.1998.5521
*cite journal | author=Yamabhai M, Hoffman NG, Hardison NL, "et al." |title=Intersectin, a novel adaptor protein with two Eps15 homology and five Src homology 3 domains. |journal=J. Biol. Chem. |volume=273 |issue= 47 |pages= 31401–7 |year= 1998 |pmid= 9813051 |doi=
*cite journal | author=Sengar AS, Wang W, Bishay J, "et al." |title=The EH and SH3 domain Ese proteins regulate endocytosis by linking to dynamin and Eps15. |journal=EMBO J. |volume=18 |issue= 5 |pages= 1159–71 |year= 1999 |pmid= 10064583 |doi= 10.1093/emboj/18.5.1159
*cite journal | author=Guipponi M, Scott HS, Hattori M, "et al." |title=Genomic structure, sequence, and refined mapping of the human intersectin gene (ITSN), which encompasses 250 kb on chromosome 21q22.1-->q22.2. |journal=Cytogenet. Cell Genet. |volume=83 |issue= 3-4 |pages= 218–20 |year= 1999 |pmid= 10072581 |doi=
*cite journal | author=Okamoto M, Schoch S, Südhof TC |title=EHSH1/intersectin, a protein that contains EH and SH3 domains and binds to dynamin and SNAP-25. A protein connection between exocytosis and endocytosis? |journal=J. Biol. Chem. |volume=274 |issue= 26 |pages= 18446–54 |year= 1999 |pmid= 10373452 |doi=
*cite journal | author=Pucharcós C, Fuentes JJ, Casas C, "et al." |title=Alu-splice cloning of human Intersectin (ITSN), a putative multivalent binding protein expressed in proliferating and differentiating neurons and overexpressed in Down syndrome. |journal=Eur. J. Hum. Genet. |volume=7 |issue= 6 |pages= 704–12 |year= 1999 |pmid= 10482960 |doi= 10.1038/sj.ejhg.5200356
*cite journal | author=Tong XK, Hussain NK, de Heuvel E, "et al." |title=The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain. |journal=EMBO J. |volume=19 |issue= 6 |pages= 1263–71 |year= 2000 |pmid= 10716926 |doi= 10.1093/emboj/19.6.1263
*cite journal | author=Fernández-Chacón R, Achiriloaie M, Janz R, "et al." |title=SCAMP1 function in endocytosis. |journal=J. Biol. Chem. |volume=275 |issue= 17 |pages= 12752–6 |year= 2000 |pmid= 10777571 |doi=
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=Pucharcos C, Estivill X, de la Luna S |title=Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis. |journal=FEBS Lett. |volume=478 |issue= 1-2 |pages= 43–51 |year= 2000 |pmid= 10922467 |doi=
*cite journal | author=Martina JA, Bonangelino CJ, Aguilar RC, Bonifacino JS |title=Stonin 2: an adaptor-like protein that interacts with components of the endocytic machinery. |journal=J. Cell Biol. |volume=153 |issue= 5 |pages= 1111–20 |year= 2001 |pmid= 11381094 |doi=
*cite journal | author=Hussain NK, Jenna S, Glogauer M, "et al." |title=Endocytic protein intersectin-l regulates actin assembly via Cdc42 and N-WASP. |journal=Nat. Cell Biol. |volume=3 |issue= 10 |pages= 927–32 |year= 2001 |pmid= 11584276 |doi= 10.1038/ncb1001-927
*cite journal | author=Pucharcos C, Casas C, Nadal M, "et al." |title=The human intersectin genes and their spliced variants are differentially expressed. |journal=Biochim. Biophys. Acta |volume=1521 |issue= 1-3 |pages= 1–11 |year= 2001 |pmid= 11690630 |doi=
*cite journal | author=Jenna S, Hussain NK, Danek EI, "et al." |title=The activity of the GTPase-activating protein CdGAP is regulated by the endocytic protein intersectin. |journal=J. Biol. Chem. |volume=277 |issue= 8 |pages= 6366–73 |year= 2002 |pmid= 11744688 |doi= 10.1074/jbc.M105516200
*cite journal | author=Snyder JT, Worthylake DK, Rossman KL, "et al." |title=Structural basis for the selective activation of Rho GTPases by Dbl exchange factors. |journal=Nat. Struct. Biol. |volume=9 |issue= 6 |pages= 468–75 |year= 2002 |pmid= 12006984 |doi= 10.1038/nsb796
*cite journal | author=Irie F, Yamaguchi Y |title=EphB receptors regulate dendritic spine development via intersectin, Cdc42 and N-WASP. |journal=Nat. Neurosci. |volume=5 |issue= 11 |pages= 1117–8 |year= 2002 |pmid= 12389031 |doi= 10.1038/nn964
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899

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