EPN1

Epsin 1, also known as EPN1, is a human gene.cite web | title = Entrez Gene: EPN1 epsin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29924| accessdate = ]

PBB_Summary
section_title =
summary_text = EPN1 is an endocytic accessory protein that interacts with EPS15 (MIM 600051), the alpha subunit of the clathrin adaptor AP2 (AP2A1; MIM 601026), and clathrin (see MIM 118960), as well as with other accessory proteins for the endocytosis of clathrin-coated vesicles. [supplied by OMIM] cite web | title = Entrez Gene: EPN1 epsin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=29924| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chen H, Fre S, Slepnev VI, "et al." |title=Epsin is an EH-domain-binding protein implicated in clathrin-mediated endocytosis. |journal=Nature |volume=394 |issue= 6695 |pages= 793–7 |year= 1998 |pmid= 9723620 |doi= 10.1038/29555
*cite journal | author=Morinaka K, Koyama S, Nakashima S, "et al." |title=Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis. |journal=Oncogene |volume=18 |issue= 43 |pages= 5915–22 |year= 1999 |pmid= 10557078 |doi= 10.1038/sj.onc.1202974
*cite journal | author=Drake MT, Downs MA, Traub LM |title=Epsin binds to clathrin by associating directly with the clathrin-terminal domain. Evidence for cooperative binding through two discrete sites. |journal=J. Biol. Chem. |volume=275 |issue= 9 |pages= 6479–89 |year= 2000 |pmid= 10692452 |doi=
*cite journal | author=Kariya K, Koyama S, Nakashima S, "et al." |title=Regulation of complex formation of POB1/epsin/adaptor protein complex 2 by mitotic phosphorylation. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18399–406 |year= 2000 |pmid= 10764745 |doi= 10.1074/jbc.M000521200
*cite journal | author=Hyman J, Chen H, Di Fiore PP, "et al." |title=Epsin 1 undergoes nucleocytosolic shuttling and its eps15 interactor NH(2)-terminal homology (ENTH) domain, structurally similar to Armadillo and HEAT repeats, interacts with the transcription factor promyelocytic leukemia Zn(2)+ finger protein (PLZF). |journal=J. Cell Biol. |volume=149 |issue= 3 |pages= 537–46 |year= 2000 |pmid= 10791968 |doi=
*cite journal | author=Drake MT, Traub LM |title=Interaction of two structurally distinct sequence types with the clathrin terminal domain beta-propeller. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28700–9 |year= 2001 |pmid= 11382783 |doi= 10.1074/jbc.M104226200
*cite journal | author=Ford MG, Mills IG, Peter BJ, "et al." |title=Curvature of clathrin-coated pits driven by epsin. |journal=Nature |volume=419 |issue= 6905 |pages= 361–6 |year= 2002 |pmid= 12353027 |doi= 10.1038/nature01020
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Koshiba S, Kigawa T, Kikuchi A, Yokoyama S |title=Solution structure of the epsin N-terminal homology (ENTH) domain of human epsin. |journal=J. Struct. Funct. Genomics |volume=2 |issue= 1 |pages= 1–8 |year= 2003 |pmid= 12836669 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Timsit YE, Miller SL, Mohney RP, O'Bryan JP |title=The U-box ligase carboxyl-terminus of Hsc 70-interacting protein ubiquitylates Epsin. |journal=Biochem. Biophys. Res. Commun. |volume=328 |issue= 2 |pages= 550–9 |year= 2005 |pmid= 15694383 |doi= 10.1016/j.bbrc.2005.01.022
*cite journal | author=Schmid EM, Ford MG, Burtey A, "et al." |title=Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. |journal=PLoS Biol. |volume=4 |issue= 9 |pages= e262 |year= 2007 |pmid= 16903783 |doi= 10.1371/journal.pbio.0040262
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026

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