L-aminoadipate-semialdehyde dehydrogenase
- L-aminoadipate-semialdehyde dehydrogenase
In enzymology, a L-aminoadipate-semialdehyde dehydrogenase (EC number|1.2.1.31) is an enzyme that catalyzes the chemical reaction
:L-2-aminoadipate 6-semialdehyde + NAD(P)+ + H2O ightleftharpoons L-2-aminoadipate + NAD(P)H + H+
The 4 substrates of this enzyme are L-2-aminoadipate 6-semialdehyde, NAD+, NADP+, and H2O, whereas its 4 products are L-2-aminoadipate, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase. Other names in common use include aminoadipate semialdehyde dehydrogenase, 2-aminoadipate semialdehyde dehydrogenase, alpha-aminoadipate-semialdehyde dehydrogenase, alpha-aminoadipate reductase, 2-aminoadipic semialdehyde dehydrogenase, L-alpha-aminoadipate delta-semialdehyde oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase, L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine, and dinucleotide oxidoreductase. This enzyme participates in lysine biosynthesis and lysine degradation.
tructural studies
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes PDB link|2BYD, PDB link|2C43, and PDB link|2CG5.
References
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External links
::"The CAS registry number for this enzyme class is CAS registry|9067-87-2."
Gene Ontology (GO) codes
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